List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Melanoma. The EFO term melanoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
F Song, CI Amos, JE Lee, CG Lian, S Fang, H Liu, S MacGregor, MM Iles, MH Law, NI Lindeman, GW Montgomery, DL Duffy, AE Cust, MA Jenkins, DC Whiteman, RF Kefford, GG Giles, BK Armstrong, JF Aitken, JL Hopper, KM Brown, NG Martin, GJ Mann, DT Bishop, JA Bishop, P Kraft, AA Qureshi, PA Kanetsky, NK Hayward, DJ Hunter, Q Wei, J Han
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer (gene x gene interaction). The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Tao, Z Wang, J Feng, FC Hsu, G Jin, ST Kim, Z Zhang, H Gronberg, LS Zheng, WB Isaacs, J Xu, J Sun
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Immune response to anthrax vaccine. The EFO term response to vaccine was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
NM Pajewski, S Shrestha, CP Quinn, SD Parker, H Wiener, B Aissani, BA McKinney, GA Poland, JC Edberg, RP Kimberly, J Tang, RA Kaslow
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
M He, M Xu, B Zhang, J Liang, P Chen, JY Lee, TA Johnson, H Li, X Yang, J Dai, L Liang, L Gui, Q Qi, J Huang, Y Li, LS Adair, T Aung, Q Cai, CY Cheng, MC Cho, YS Cho, M Chu, B Cui, YT Gao, MJ Go, D Gu, W Gu, H Guo, Y Hao, J Hong, Z Hu, Y Hu, J Huang, JY Hwang, MK Ikram, G Jin, DH Kang, CC Khor, BJ Kim, HT Kim, M Kubo, J Lee, J Lee, NR Lee, R Li, J Li, J Liu, J Longe, W Lu, X Lu, X Miao, Y Okada, RT Ong, G Qiu, M Seielstad, X Sim, H Song, F Takeuchi, T Tanaka, PR Taylor, L Wang, W Wang, Y Wang, C Wu, Y Wu, YB Xiang, K Yamamoto, H Yang, M Liao, M Yokota, T Young, X Zhang, N Kato, QK Wang, W Zheng, FB Hu, D Lin, H Shen, YY Teo, Z Mo, TY Wong, X Lin, KL Mohlke, G Ning, T Tsunoda, BG Han, XO Shu, ES Tai, T Wu, L Qi
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Post bronchodilator FEV1/FVC ratio. The EFO term response to bronchodilator, FEV/FEC ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SM Lutz, MH Cho, K Young, CP Hersh, PJ Castaldi, ML McDonald, E Regan, M Mattheisen, DL DeMeo, M Parker, M Foreman, BJ Make, RL Jensen, R Casaburi, DA Lomas, SP Bhatt, P Bakke, A Gulsvik, JD Crapo, TH Beaty, NM Laird, C Lange, JE Hokanson, EK Silverman
GWAS: forced expiratory volume, response to bronchodilator
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Post bronchodilator FEV1. The EFO term forced expiratory volume, response to bronchodilator was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SM Lutz, MH Cho, K Young, CP Hersh, PJ Castaldi, ML McDonald, E Regan, M Mattheisen, DL DeMeo, M Parker, M Foreman, BJ Make, RL Jensen, R Casaburi, DA Lomas, SP Bhatt, P Bakke, A Gulsvik, JD Crapo, TH Beaty, NM Laird, C Lange, JE Hokanson, EK Silverman
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
H Lango Allen, K Estrada, G Lettre, SI Berndt, MN Weedon, F Rivadeneira, CJ Willer, AU Jackson, S Vedantam, S Raychaudhuri, T Ferreira, AR Wood, RJ Weyant, AV Segrè, EK Speliotes, E Wheeler, N Soranzo, JH Park, J Yang, D Gudbjartsson, NL Heard-Costa, JC Randall, L Qi, A Vernon Smith, R Mägi, T Pastinen, L Liang, IM Heid, J Luan, G Thorleifsson, TW Winkler, ME Goddard, K Sin Lo, C Palmer, T Workalemahu, YS Aulchenko, A Johansson, MC Zillikens, MF Feitosa, T Esko, T Johnson, S Ketkar, P Kraft, M Mangino, I Prokopenko, D Absher, E Albrecht, F Ernst, NL Glazer, C Hayward, JJ Hottenga, KB Jacobs, JW Knowles, Z Kutalik, KL Monda, O Polasek, M Preuss, NW Rayner, NR Robertson, V Steinthorsdottir, JP Tyrer, BF Voight, F Wiklund, J Xu, JH Zhao, DR Nyholt, N Pellikka, M Perola, JR Perry, I Surakka, ML Tammesoo, EL Altmaier, N Amin, T Aspelund, T Bhangale, G Boucher, DI Chasman, C Chen, L Coin, MN Cooper, AL Dixon, Q Gibson, E Grundberg, K Hao, M Juhani Junttila, LM Kaplan, J Kettunen, IR König, T Kwan, RW Lawrence, DF Levinson, M Lorentzon, B McKnight, AP Morris, M Müller, J Suh Ngwa, S Purcell, S Rafelt, RM Salem, E Salvi, S Sanna, J Shi, U Sovio, JR Thompson, MC Turchin, L Vandenput, DJ Verlaan, V Vitart, CC White, A Ziegler, P Almgren, AJ Balmforth, H Campbell, L Citterio, A De Grandi, A Dominiczak, J Duan, P Elliott, R Elosua, JG Eriksson, NB Freimer, EJ Geus, N Glorioso, S Haiqing, AL Hartikainen, AS Havulinna, AA Hicks, J Hui, W Igl, T Illig, A Jula, E Kajantie, TO Kilpeläinen, M Koiranen, I Kolcic, S Koskinen, P Kovacs, J Laitinen, J Liu, ML Lokki, A Marusic, A Maschio, T Meitinger, A Mulas, G Paré, AN Parker, JF Peden, A Petersmann, I Pichler, KH Pietiläinen, A Pouta, M Ridderstråle, JI Rotter, JG Sambrook, AR Sanders, CO Schmidt, J Sinisalo, JH Smit, HM Stringham, G Bragi Walters, E Widen, SH Wild, G Willemsen, L Zagato, L Zgaga, P Zitting, H Alavere, M Farrall, WL McArdle, M Nelis, MJ Peters, S Ripatti, JB van Meurs, KK Aben, KG Ardlie, JS Beckmann, JP Beilby, RN Bergman, S Bergmann, FS Collins, D Cusi, M den Heijer, G Eiriksdottir, PV Gejman, AS Hall, A Hamsten, HV Huikuri, C Iribarren, M Kähönen, J Kaprio, S Kathiresan, L Kiemeney, T Kocher, LJ Launer, T Lehtimäki, O Melander, TH Mosley, AW Musk, MS Nieminen, CJ O'Donnell, C Ohlsson, B Oostra, LJ Palmer, O Raitakari, PM Ridker, JD Rioux, A Rissanen, C Rivolta, H Schunkert, AR Shuldiner, DS Siscovick, M Stumvoll, A Tönjes, J Tuomilehto, GJ van Ommen, J Viikari, AC Heath, NG Martin, GW Montgomery, MA Province, M Kayser, AM Arnold, LD Atwood, E Boerwinkle, SJ Chanock, P Deloukas, C Gieger, H Grönberg, P Hall, AT Hattersley, C Hengstenberg, W Hoffman, GM Lathrop, V Salomaa, S Schreiber, M Uda, D Waterworth, AF Wright, TL Assimes, I Barroso, A Hofman, KL Mohlke, DI Boomsma, MJ Caulfield, LA Cupples, J Erdmann, CS Fox, V Gudnason, U Gyllensten, TB Harris, RB Hayes, MR Jarvelin, V Mooser, PB Munroe, WH Ouwehand, BW Penninx, PP Pramstaller, T Quertermous, I Rudan, NJ Samani, TD Spector, H Völzke, H Watkins, JF Wilson, LC Groop, T Haritunians, FB Hu, RC Kaplan, A Metspalu, KE North, D Schlessinger, NJ Wareham, DJ Hunter, JR O'Connell, DP Strachan, HE Wichmann, IB Borecki, CM van Duijn, EE Schadt, U Thorsteinsdottir, L Peltonen, AG Uitterlinden, PM Visscher, N Chatterjee, RJ Loos, M Boehnke, MI McCarthy, E Ingelsson, CM Lindgren, GR Abecasis, K Stefansson, TM Frayling, JN Hirschhorn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SI Berndt, S Gustafsson, R Mägi, A Ganna, E Wheeler, MF Feitosa, AE Justice, KL Monda, DC Croteau-Chonka, FR Day, T Esko, T Fall, T Ferreira, D Gentilini, AU Jackson, J Luan, JC Randall, S Vedantam, CJ Willer, TW Winkler, AR Wood, T Workalemahu, YJ Hu, SH Lee, L Liang, DY Lin, JL Min, BM Neale, G Thorleifsson, J Yang, E Albrecht, N Amin, JL Bragg-Gresham, G Cadby, M den Heijer, N Eklund, K Fischer, A Goel, JJ Hottenga, JE Huffman, I Jarick, Å Johansson, T Johnson, S Kanoni, ME Kleber, IR König, K Kristiansson, Z Kutalik, C Lamina, C Lecoeur, G Li, M Mangino, WL McArdle, C Medina-Gomez, M Müller-Nurasyid, JS Ngwa, IM Nolte, L Paternoster, S Pechlivanis, M Perola, MJ Peters, M Preuss, LM Rose, J Shi, D Shungin, AV Smith, RJ Strawbridge, I Surakka, A Teumer, MD Trip, J Tyrer, JV Van Vliet-Ostaptchouk, L Vandenput, LL Waite, JH Zhao, D Absher, FW Asselbergs, M Atalay, AP Attwood, AJ Balmforth, H Basart, J Beilby, LL Bonnycastle, P Brambilla, M Bruinenberg, H Campbell, DI Chasman, PS Chines, FS Collins, JM Connell, WO Cookson, U de Faire, F de Vegt, M Dei, M Dimitriou, S Edkins, K Estrada, DM Evans, M Farrall, MM Ferrario, J Ferrières, L Franke, F Frau, PV Gejman, H Grallert, H Grönberg, V Gudnason, AS Hall, P Hall, AL Hartikainen, C Hayward, NL Heard-Costa, AC Heath, J Hebebrand, G Homuth, FB Hu, SE Hunt, E Hyppönen, C Iribarren, KB Jacobs, JO Jansson, A Jula, M Kähönen, S Kathiresan, F Kee, KT Khaw, M Kivimäki, W Koenig, AT Kraja, M Kumari, K Kuulasmaa, J Kuusisto, JH Laitinen, TA Lakka, C Langenberg, LJ Launer, L Lind, J Lindström, J Liu, A Liuzzi, ML Lokki, M Lorentzon, PA Madden, PK Magnusson, P Manunta, D Marek, W März, I Mateo Leach, B McKnight, SE Medland, E Mihailov, L Milani, GW Montgomery, V Mooser, TW Mühleisen, PB Munroe, AW Musk, N Narisu, G Navis, G Nicholson, EA Nohr, KK Ong, BA Oostra, CN Palmer, A Palotie, JF Peden, N Pedersen, A Peters, O Polasek, A Pouta, PP Pramstaller, I Prokopenko, C Pütter, A Radhakrishnan, O Raitakari, A Rendon, F Rivadeneira, I Rudan, TE Saaristo, JG Sambrook, AR Sanders, S Sanna, J Saramies, S Schipf, S Schreiber, H Schunkert, SY Shin, S Signorini, J Sinisalo, B Skrobek, N Soranzo, A Stančáková, K Stark, JC Stephens, K Stirrups, RP Stolk, M Stumvoll, AJ Swift, EV Theodoraki, B Thorand, DA Tregouet, E Tremoli, MM Van der Klauw, JB van Meurs, SH Vermeulen, J Viikari, J Virtamo, V Vitart, G Waeber, Z Wang, E Widén, SH Wild, G Willemsen, BR Winkelmann, JC Witteman, BH Wolffenbuttel, A Wong, AF Wright, MC Zillikens, P Amouyel, BO Boehm, E Boerwinkle, DI Boomsma, MJ Caulfield, SJ Chanock, LA Cupples, D Cusi, GV Dedoussis, J Erdmann, JG Eriksson, PW Franks, P Froguel, C Gieger, U Gyllensten, A Hamsten, TB Harris, C Hengstenberg, AA Hicks, A Hingorani, A Hinney, A Hofman, KG Hovingh, K Hveem, T Illig, MR Jarvelin, KH Jöckel, SM Keinanen-Kiukaanniemi, LA Kiemeney, D Kuh, M Laakso, T Lehtimäki, DF Levinson, NG Martin, A Metspalu, AD Morris, MS Nieminen, I Njølstad, C Ohlsson, AJ Oldehinkel, WH Ouwehand, LJ Palmer, B Penninx, C Power, MA Province, BM Psaty, L Qi, R Rauramaa, PM Ridker, S Ripatti, V Salomaa, NJ Samani, H Snieder, TI Sørensen, TD Spector, K Stefansson, A Tönjes, J Tuomilehto, AG Uitterlinden, M Uusitupa, P van der Harst, P Vollenweider, H Wallaschofski, NJ Wareham, H Watkins, HE Wichmann, JF Wilson, GR Abecasis, TL Assimes, I Barroso, M Boehnke, IB Borecki, P Deloukas, CS Fox, T Frayling, LC Groop, T Haritunian, IM Heid, D Hunter, RC Kaplan, F Karpe, MF Moffatt, KL Mohlke, JR O'Connell, Y Pawitan, EE Schadt, D Schlessinger, V Steinthorsdottir, DP Strachan, U Thorsteinsdottir, CM van Duijn, PM Visscher, AM Di Blasio, JN Hirschhorn, CM Lindgren, AP Morris, D Meyre, A Scherag, MI McCarthy, EK Speliotes, KE North, RJ Loos, E Ingelsson
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Educational attainment (college completion). The EFO term self reported educational attainment was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Okbay, JP Beauchamp, MA Fontana, JJ Lee, TH Pers, CA Rietveld, P Turley, GB Chen, V Emilsson, SF Meddens, S Oskarsson, JK Pickrell, K Thom, P Timshel, R de Vlaming, A Abdellaoui, TS Ahluwalia, J Bacelis, C Baumbach, G Bjornsdottir, JH Brandsma, M Pina Concas, J Derringer, NA Furlotte, TE Galesloot, G Girotto, R Gupta, LM Hall, SE Harris, E Hofer, M Horikoshi, JE Huffman, K Kaasik, IP Kalafati, R Karlsson, A Kong, J Lahti, SJ van der Lee, C deLeeuw, PA Lind, KO Lindgren, T Liu, M Mangino, J Marten, E Mihailov, MB Miller, PJ van der Most, C Oldmeadow, A Payton, N Pervjakova, WJ Peyrot, Y Qian, O Raitakari, R Rueedi, E Salvi, B Schmidt, KE Schraut, J Shi, AV Smith, RA Poot, B St Pourcain, A Teumer, G Thorleifsson, N Verweij, D Vuckovic, J Wellmann, HJ Westra, J Yang, W Zhao, Z Zhu, BZ Alizadeh, N Amin, A Bakshi, SE Baumeister, G Biino, K Bønnelykke, PA Boyle, H Campbell, FP Cappuccio, G Davies, JE De Neve, P Deloukas, I Demuth, J Ding, P Eibich, L Eisele, N Eklund, DM Evans, JD Faul, MF Feitosa, AJ Forstner, I Gandin, B Gunnarsson, BV Halldórsson, TB Harris, AC Heath, LJ Hocking, EG Holliday, G Homuth, MA Horan, JJ Hottenga, PL de Jager, PK Joshi, A Jugessur, MA Kaakinen, M Kähönen, S Kanoni, L Keltigangas-Järvinen, LA Kiemeney, I Kolcic, S Koskinen, AT Kraja, M Kroh, Z Kutalik, A Latvala, LJ Launer, MP Lebreton, DF Levinson, P Lichtenstein, P Lichtner, DC Liewald, A Loukola, PA Madden, R Mägi, T Mäki-Opas, RE Marioni, P Marques-Vidal, GA Meddens, G McMahon, C Meisinger, T Meitinger, Y Milaneschi, L Milani, GW Montgomery, R Myhre, CP Nelson, DR Nyholt, WE Ollier, A Palotie, L Paternoster, NL Pedersen, KE Petrovic, DJ Porteous, K Räikkönen, SM Ring, A Robino, O Rostapshova, I Rudan, A Rustichini, V Salomaa, AR Sanders, AP Sarin, H Schmidt, RJ Scott, BH Smith, JA Smith, JA Staessen, E Steinhagen-Thiessen, K Strauch, A Terracciano, MD Tobin, S Ulivi, S Vaccargiu, L Quaye, FJ van Rooij, C Venturini, AA Vinkhuyzen, U Völker, H Völzke, JM Vonk, D Vozzi, J Waage, EB Ware, G Willemsen, JR Attia, DA Bennett, K Berger, L Bertram, H Bisgaard, DI Boomsma, IB Borecki, U Bültmann, CF Chabris, F Cucca, D Cusi, IJ Deary, GV Dedoussis, CM van Duijn, JG Eriksson, B Franke, L Franke, P Gasparini, PV Gejman, C Gieger, HJ Grabe, J Gratten, PJ Groenen, V Gudnason, P van der Harst, C Hayward, DA Hinds, W Hoffmann, E Hyppönen, WG Iacono, B Jacobsson, MR Järvelin, KH Jöckel, J Kaprio, SL Kardia, T Lehtimäki, SF Lehrer, PK Magnusson, NG Martin, M McGue, A Metspalu, N Pendleton, BW Penninx, M Perola, N Pirastu, M Pirastu, O Polasek, D Posthuma, C Power, MA Province, NJ Samani, D Schlessinger, R Schmidt, TI Sørensen, TD Spector, K Stefansson, U Thorsteinsdottir, AR Thurik, NJ Timpson, H Tiemeier, JY Tung, AG Uitterlinden, V Vitart, P Vollenweider, DR Weir, JF Wilson, AF Wright, DC Conley, RF Krueger, G Davey Smith, A Hofman, DI Laibson, SE Medland, MN Meyer, J Yang, M Johannesson, PM Visscher, T Esko, PD Koellinger, D Cesarini, DJ Benjamin
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Ulcerative colitis. The EFO term ulcerative colitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JZ Liu, S van Sommeren, H Huang, SC Ng, R Alberts, A Takahashi, S Ripke, JC Lee, L Jostins, T Shah, S Abedian, JH Cheon, J Cho, NE Daryani, L Franke, Y Fuyuno, A Hart, RC Juyal, G Juyal, WH Kim, AP Morris, H Poustchi, WG Newman, V Midha, TR Orchard, H Vahedi, A Sood, JJ Sung, R Malekzadeh, HJ Westra, K Yamazaki, SK Yang, JC Barrett, A Franke, BZ Alizadeh, M Parkes, T B K, MJ Daly, M Kubo, CA Anderson, RK Weersma
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Hippocampus Gene Expression Correlates for SALINE_ACOUNT_2 measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SALINE_ACOUNT_2 measures Open Field TOTAL locomotion (activity beam breaks) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SALINE_ADIST_2 measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SALINE_ADIST_2 measures Open Field TOTAL locomotion ( cm in 1 hr) under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SALINE_VCOUNT_2 measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SALINE_VCOUNT_2 measures Open Field TOTAL rears post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHCOUNT15 measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHCOUNT15 measures Open Field - locomotion (activity beam breaks) 0-15 min under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SHDIST15 measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SHDIST15 measures Open Field - Total horizontal distance (cm) 0-15 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SVCOUNT60 measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SVCOUNT60 measures Open Field Rears 45-60 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
cocaine related behavior 4 (Cocrb4) spans 120.266777 - 170.266777 Mbp (NCBI Build 37) on Chr 3. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for ethanol conditioned taste aversion on Chr3 at D3Mit11 (111.75 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 86.75 - 136.75 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for body temperature on Chr3 at Gnat2 (111.75 Mbp , Build 37)
Description:
METH responses for body temperature spans 86.75 - 136.75 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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