DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Post bronchodilator FEV1/FVC ratio. The EFO term response to bronchodilator, FEV/FEC ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: response to bronchodilator, FEV/FEC ratio

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

SM Lutz, MH Cho, K Young, CP Hersh, PJ Castaldi, ML McDonald, E Regan, M Mattheisen, DL DeMeo, M Parker, M Foreman, BJ Make, RL Jensen, R Casaburi, DA Lomas, SP Bhatt, P Bakke, A Gulsvik, JD Crapo, TH Beaty, NM Laird, C Lange, JE Hokanson, EK Silverman

TITLE:

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

JOURNAL:

BMC genetics Dec 2015, Vol 16, pp. 138

ABSTRACT:

Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). PUBMED: 26634245
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