DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body height

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

161

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

M He, M Xu, B Zhang, J Liang, P Chen, JY Lee, TA Johnson, H Li, X Yang, J Dai, L Liang, L Gui, Q Qi, J Huang, Y Li, LS Adair, T Aung, Q Cai, CY Cheng, MC Cho, YS Cho, M Chu, B Cui, YT Gao, MJ Go, D Gu, W Gu, H Guo, Y Hao, J Hong, Z Hu, Y Hu, J Huang, JY Hwang, MK Ikram, G Jin, DH Kang, CC Khor, BJ Kim, HT Kim, M Kubo, J Lee, J Lee, NR Lee, R Li, J Li, J Liu, J Longe, W Lu, X Lu, X Miao, Y Okada, RT Ong, G Qiu, M Seielstad, X Sim, H Song, F Takeuchi, T Tanaka, PR Taylor, L Wang, W Wang, Y Wang, C Wu, Y Wu, YB Xiang, K Yamamoto, H Yang, M Liao, M Yokota, T Young, X Zhang, N Kato, QK Wang, W Zheng, FB Hu, D Lin, H Shen, YY Teo, Z Mo, TY Wong, X Lin, KL Mohlke, G Ning, T Tsunoda, BG Han, XO Shu, ES Tai, T Wu, L Qi

TITLE:

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

JOURNAL:

Human molecular genetics Mar 2015, Vol 24, pp. 1791-800

ABSTRACT:

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians. PUBMED: 25429064
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