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Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
Gene expression correlation with morphine response in BXD mice
Description:
Dataset represents the correlation between gene expression in prefrontal cortex from GeneNetwork dataset DOD BXD PFC GWI CTL RNA-seq ComB (Dec19) TPM Log2 with GeneNetwork dataset for BXD mice labeled as: Central nervous system, pharmacology, behavior: Morphine response (50 mg/kg ip), locomotion (open field) from 45-60 min after injection in an activity chamber for males [cm] with peak at Chr10: 5.636905. Data shown here are p-adjusted values < 0.05.
Average rotarod training latency Chr# 6 rs6239023 (94005991) with right flanking marker rs3672029(75345665) and left marker rs30316697(130188177). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with B.burgdorferi-associated arthritis 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (138924847)
Authors:
Weis JJ, McCracken BA, Ma Y, Fairbairn D, Roper RJ, Morrison TB, Weis JH, Zachary JF, Doerge RW, Teuscher C
QTL associated with bronchial hyperresponsiveness 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (115192871)
Authors:
Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR
QTL associated with cadmium-induced forelimb autopod reduction defect. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (148406472)
Authors:
Hovland DN Jr, Cantor RM, Lee GS, Machado AF, Collins MD
QTL associated with cystic fibrosis body weight 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111954645)
QTL associated with collagen induced arthritis QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (113297319)
QTL associated with experimental autoimmune myocarditis 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147000978)
Authors:
Guler ML, Ligons DL, Wang Y, Bianco M, Broman KW, Rose NR
QTL associated with gastritis type A susceptibility locus 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (105955399)
Authors:
Baxter AG, Jordan MA, Silveira PA, Wilson WE, Van Driel IR
QTL associated with immediate cutaneous hypersensitivity QTL. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (107745604)
Authors:
Daser A, Koetz K, Btjer N, Jung M, Rschendorf F, Goltz M, Ellerbrok H, Renz H, Walter J, Paulsen M