DESCRIPTION:

QTL associated with experimental autoimmune myocarditis 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (147000978)

LABEL:

QTL-Eamcd2-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3574853

AUTHORS:

Guler ML, Ligons DL, Wang Y, Bianco M, Broman KW, Rose NR

TITLE:

Two autoimmune diabetes loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis.

JOURNAL:

Journal of immunology (Baltimore, Md. : 1950) Feb 2005, Vol 174, pp. 2167-73

ABSTRACT:

The pathogenesis of immune-mediated myocarditis depends on genetic and environmental factors. To study the genetic mechanisms, we have developed a model of experimental autoimmune myocarditis in the A.SW mouse. Here we provide evidence that loci on murine chromosome 6, and possibly chromosome 1, are involved in regulating susceptibility. Moreover, these loci overlap with loci implicated in other autoimmune diseases including diabetes in the NOD mouse. These two loci also regulate apoptosis in thymocytes as well as peripheral T cells in the NOD mouse, and we report further that A.SW mice demonstrate the same characteristics in apoptosis. These results suggest that common pathogenetic mechanisms involving apoptosis of both thymic and peripheral T cells are shared by multiple autoimmune diseases. PUBMED: 15699148
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