DESCRIPTION:

QTL associated with gastritis type A susceptibility locus 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (105955399)

LABEL:

QTL-Gasa3-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2176188

AUTHORS:

Baxter AG, Jordan MA, Silveira PA, Wilson WE, Van Driel IR

TITLE:

Genetic control of susceptibility to autoimmune gastritis.

JOURNAL:

International reviews of immunology Jan-Apr 2005, Vol 24, pp. 55-62

ABSTRACT:

A familial component to the tendency to develop autoimmune gastritis has long been recognized. Although linkage to certain HLA alleles and an association with the endocrine autoimmune diseases thyroiditis and type 1 diabetes have been reported, little further progress has been achieved in clinical studies. In contrast, the mouse model of gastritis induced in the BALB/c strain by thymectomy in the third day of life has identified four linkage regions; two on distal chromosome 4 (Gasa1 and Gasa2), one on chromosome 6 (Gasa3) and one in the H2 (Gasa4). Three of these four genes colocalize with NOD mouse diabetes susceptibility genes--the strongest concordance identified to date between any two autoimmune diseases--reflecting the association between autoimmune diabetes and type 1 gastritis in humans. PUBMED: 15763989
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