GeneSet Information

Tier II GS136051 • IGF-1 serum levels 1 (Igf1sl1, Published QTL Chr 6)

DESCRIPTION:

QTL associated with IGF-1 serum levels 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (116105146)

LABEL:

QTL-Igf1sl1-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3046873

AUTHORS:

Shai SY, Sukhanov S, Higashi Y, Vaughn C, Rosen CJ, Delafontaine P

TITLE:

Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice.

JOURNAL:

American journal of physiology. Heart and circulatory physiology May 2011, Vol 300, pp. H1898-906

ABSTRACT:

Some clinical studies have suggested that lower IGF-I levels may be associated with an increased risk of ischemic heart disease. We generated atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice with 6T alleles (6T/ApoE(-/-) mice) with a 20% decline in circulating IGF-I and fed these mice and control ApoE(-/-) mice with normal chow or a Western diet for 12 wk to evaluate the effect of low serum IGF-I on atherosclerosis progression. We found that the 6T/ApoE(-/-) phenotype was characterized by an increased atherosclerotic burden, elevated plaque macrophages, and increased proinflammatory cytokine TNF-α levels compared with ApoE(-/-) controls. 6T/ApoE(-/-) mice had similar body weight, blood pressure, serum total cholesterol levels, total plaque and smooth muscle cell apoptosis rates, and circulating levels of endothelial progenitor cells as ApoE(-/-) mice. 6T/ApoE(-/-) mice fed with normal chow had reduced vascular endothelial nitric oxide synthase mRNA levels and a trend to increased aortic expression of chemokine (C-C motif) receptor (CCR)1, CCR2, and monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2. Western diet-fed 6T/ApoE(-/-) mice had a trend to increased expression of macrophage scavenger receptor-1/scavenger receptor-A, osteopontin, ATP-binding cassette (subfamily A, member 1), and angiotensin-converting enzyme and elevated circulating levels of the neutrophil chemoattractant chemokine (C-X-C motif) ligand 1 (KC). Our data establish a link between lower circulating IGF-I and increased atherosclerosis that has important clinical implications. PUBMED: 21335474
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Annotation Information

No sequence read archive data associated with this GeneSet.


Growth (D006128)
Alleles (D000483)
Pressure (D011312)
Insulin-Like Growth Factor I (D007334)
Osteopontin (D053495)
Serum (D044967)
Mice (D051379)
Heart Diseases (D006331)
Myocytes, Smooth Muscle (D032389)
RNA, Messenger (D012333)
Nitric Oxide Synthase (D019001)
Fibrinogen (D005340)
Nitric Oxide Synthase Type III (D052250)
Risk (D012306)
Chemokine CCL2 (D018932)
Cholesterol (D002784)
Monocytes (D009000)
Blood Pressure (D001794)
Neutrophils (D009504)
Muscles (D009132)
Muscle, Smooth (D009130)
Cells (D002477)
Blood (D001769)
Muscle Cells (D032342)
Apolipoproteins (D001053)
Stem Cells (D013234)
Chemokine CXCL1 (D054360)
Nitric Oxide (D009569)
Atherosclerosis (D050197)
Body Weight (D001835)
Heart (D006321)
Macrophages (D008264)
Diet (D004032)
Apoptosis (D017209)
Myocardial Ischemia (D017202)
blood (MA:0000059)
heart (MA:0000072)
serum (MA:0002502)
atherosclerotic lesions (MP:0005338)
cell (GO:0005623)
growth (GO:0040007)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351