Using a two-stage process, several genes were initially identified using microarray analyses of cerebellar tissue from ethanol-treated PKCgamma mutant and wild-type mice. This geneset consists of genes related to PKCgamma mutant expression changes due to chronic ethanol diet.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
Differentially expressed in the Nucleus accumbens following 24 hr continuous 9.5g/kg/day alcohol drinking vs. water drinking in alcohol preferring rats. Estimated BAC in the alcohol exposed group was > 85mg%. The 406 significanlty different probe sets represent 374 uniquely named genes, with most gene expression differences in the range of 1.1-1.3 fold.
Using a two-stage process, several genes were initially identified using microarray analyses of cerebellar tissue from ethanol-treated PKCgamma mutant and wild-type mice. This geneset consists of genes related to PKCgamma wild-type expression changes due to chronic ethanol diet.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
Using a two-stage process, several genes were initially identified using microarray analyses of cerebellar tissue from ethanol-treated PKCgamma mutant and wild-type mice. This geneset consists of genes related to PKCgamma mutant expression changes due to chronic ethanol diet.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
Study shows that PKC-gamma wild-type mice develop tolerance to the sedative- hypnotic effects of ethanol after chronic ethanol treatment but mutant mice do not, making these genotypes a suitable model for identifying changes in gene expression related developing tolerance toward ethanol. This gene set comprises 27 ethanol- dependence genes that were upregulated in the PKC-gamma wild-type mice during the experiment.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
This gene set comprises 17 ethanol-dependence genes that were downregulated in the PKC-gamma wild-type mice during the experiment. Background: Study shows that PKC-gamma wild-type mice develop tolerance to the sedative-hypnotic effects of ethanol after chronic ethanol treatment but mutant mice do not, making these genotypes a suitable model for identifying changes in gene expression related developing tolerance toward ethanol.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
This gene set comprises 26 ethanol-dependence genes that were upregulated in the PKC-gamma mutant mice during the experiment. Background: Study shows that PKC- gamma wild-type mice develop tolerance to the sedative-hypnotic effects of ethanol after chronic ethanol treatment but mutant mice do not, making these genotypes a suitable model for identifying changes in gene expression related developing tolerance toward ethanol.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
This gene set comprises 17 ethanol-dependence genes that were downregulated in the PKC-gamma mutant mice tested during the experiment. Background: Study shows that PKC-gamma wild-type mice develop tolerance to the sedative-hypnotic effects of ethanol after chronic ethanol treatment but mutant mice do not, making these genotypes a suitable model for identifying changes in gene expression related developing tolerance toward ethanol.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
Neocortex Gene Expression Correlates for LM_CUE_SUPPRESS measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The LM_CUE_SUPPRESS measures Suppression of activity in altered context under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for ROTATRAIN_TIME measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The ROTATRAIN_TIME measures Mean time on rotarod during training. under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for ST_MAX_120 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The ST_MAX_120 measures Maximum startle to 120 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for ST_MAX_70 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The ST_MAX_70 measures Maximum startle response to 70 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Bolus fed rats (6g/kg/body weight, 20% ethanol solution) or rats maintained on an intragatric liquid ethanol diet (13/g/kg/d) for a month were compared with controls. Bolus fed rats were killed 3 or 12 hours post alcohol, with alcohol and blood levels taken. Ethanol fed rats were killed at either peak or trough of the urinary alcohol cycle (UAL). Data set is comparison of the experimental group versus control during peak UAL in hepatocytes.
Authors:
Bardag-Gorce F, Oliva J, Dedes J, Li J, French BA, French SW
Bolus fed rats (6g/kg/body weight, 20% ethanol solution) or rats maintained on an intragatric liquid ethanol diet (13/g/kg/d) for a month were compared with controls. Bolus fed rats were killed 3 or 12 hours post alcohol, with alcohol and blood levels taken. Ethanol fed rats were killed at either peak or trough of the urinary alcohol cycle (UAL). Data set is comparison of the experimental group versus control during trough UAL in hepatocytes.
Authors:
Bardag-Gorce F, Oliva J, Dedes J, Li J, French BA, French SW
Bolus fed rats (6g/kg/body weight, 20% ethanol solution) or rats maintained on an intragatric liquid ethanol diet (13/g/kg/d) for a month were compared with controls. Bolus fed rats were killed 3 or 12 hours post alcohol, with alcohol and blood levels taken. Ethanol fed rats were killed at either peak or trough of the urinary alcohol cycle (UAL). Data set is comparison of the experimental group versus control, 3 hours after ethanol bolus.
Authors:
Bardag-Gorce F, Oliva J, Dedes J, Li J, French BA, French SW
Bolus fed rats (6g/kg/body weight, 20% ethanol solution) or rats maintained on an intragatric liquid ethanol diet (13/g/kg/d) for a month were compared with controls. Bolus fed rats were killed 3 or 12 hours post alcohol, with alcohol and blood levels taken. Ethanol fed rats were killed at either peak or trough of the urinary alcohol cycle (UAL). Data set is comparison of the experimental group versus control, 12 hours after ethanol bolus.
Authors:
Bardag-Gorce F, Oliva J, Dedes J, Li J, French BA, French SW
A list of genes whose transcript abundance in the PFC changed significantly 4 hours after an acute dose of ethanol (1.8 g/kg). This list was generated using Fisher's Combined Probability test to analyze saline vs ethanol S-scores across B6 and D2 inbred strains (n=3) and 27 BXD RI lines (n=1). Statistical significance was determined using 1,000 permutations of S-score data and selecting for probe-sets with q-values < 0.05. Aaron Wolen 5-26-10.
Authors:
Wolen AR, Phillips CA, Langston MA, Putman AH, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF
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