GeneSet Information

Tier III GS37166 • Upregulated genes in hepatocytes, one month after chronic ethanol 13/g/kg/d

DESCRIPTION:

Bolus fed rats (6g/kg/body weight, 20% ethanol solution) or rats maintained on an intragatric liquid ethanol diet (13/g/kg/d) for a month were compared with controls. Bolus fed rats were killed 3 or 12 hours post alcohol, with alcohol and blood levels taken. Ethanol fed rats were killed at either peak or trough of the urinary alcohol cycle (UAL). Data set is comparison of the experimental group versus control during trough UAL in hepatocytes.

LABEL:

EtOH upregulation

SCORE TYPE:

Binary

DATE ADDED:

2010-01-14

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Bardag-Gorce F, Oliva J, Dedes J, Li J, French BA, French SW

TITLE:

Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding.

JOURNAL:

Alcoholism, clinical and experimental research Apr 2009, Vol 33, pp. 684-92

ABSTRACT:

BACKGROUND: Gene expression changes in the liver after acute binge drinking may differ from the changes seen in chronic ethanol feeding in the rat. The changes in gene expression after chronic ethanol feeding may sensitize the liver to alcohol-induced liver damage, which is not seen after acute binge drinking. METHODS: To test this hypothesis, gene microarray analysis was performed on the livers of rats (n = 3) fed an acute binge dose of ethanol (6 g/kg body wt) and killed at 3 and 12 hours after ethanol by gavage. The gene microarrays were compared with those made on the liver of rats from a previous study, in which the rats were fed ethanol by intragastric tube for 1 month (36% of calories derived from ethanol). RESULTS: Microarray analysis data varied between the acute and chronic models in several important respects. Growth factors increased mainly in the chronic alcohol fed rat. Changes in enzymes involved in oxidative stress were noted only with chronic ethanol feeding. Gene expression of fat metabolism was increased only with chronic ethanol feeding. Most importantly, epigenetic related enzymes and acetylation and methylation of histones changed only after chronic ethanol feeding. CONCLUSIONS: The results support the concept that chronic ethanol ingestion induces altered gene expression as a result of changes in epigenetic mechanisms, where acetylation and methylation of histones were altered. PUBMED: 19170665
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Annotation Information

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Growth (D006128)
Eating (D004435)
Gene Expression Regulation (D005786)
Drinking (D004326)
Animals (D000818)
Memory (D008568)
Hepatocytes (D022781)
Microarray Analysis (D046228)
Central Nervous System Depressants (D002492)
Enzymes (D004798)
Liver (D008099)
Epigenesis, Genetic (D044127)
Intercellular Signaling Peptides and Proteins (D036341)
Rats (D051381)
Acetylation (D000107)
Oxidative Stress (D018384)
Epigenomics (D057890)
Oligonucleotide Array Sequence Analysis (D020411)
Disease Models, Animal (D004195)
Chronic Disease (D002908)
Blood (D001769)
Methods (D008722)
Acute Disease (D000208)
Dose-Response Relationship, Drug (D004305)
Body Weight (D001835)
Set (Psychology) (D012718)
Histones (D006657)
Diet (D004032)
Alcoholism (D000437)
Ethanol (D000431)
Metabolism (D008660)
Rats, Wistar (D017208)
Methylation (D008745)
blood (MA:0000059)
liver (MA:0000358)
adipose tissue (MA:0000009)
oxidative stress (MP:0003674)
metabolic process (GO:0008152)
methylation (GO:0032259)
growth (GO:0040007)
gene expression (GO:0010467)
memory (GO:0007613)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351