The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
QTL associated with bleomycin pulmonary fibrosis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35216590)
QTL associated with gastritis type A susceptibility locus 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (44392666)
Authors:
Baxter AG, Jordan MA, Silveira PA, Wilson WE, Van Driel IR
QTL associated with trypanosome infection response 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33737692)
Authors:
Rathkolb B, Noyes HA, Brass A, Dark P, Fuchs H, Gailus-Durner V, Gibson J, de Angelis MH, Ogugo M, Iraqi F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M
QTL associated with insulin dependent diabetes susceptibility 16. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33737692)
QTL associated with SGC/Knj cross B6 QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34380179)
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with adenovirus induced hyperthyroidism 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (47859524)
Authors:
Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM
QTL associated with cerebral malaria susceptibility in CBA/N. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34137861)
QTL associated with pulmonary adenoma susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33737692)
Authors:
Wang M, Lemon WJ, Liu G, Wang Y, Iraqi FA, Malkinson AM, You M
QTL associated with UVB induced immunosuppression 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45448429)
Authors:
Clemens KE, Churchill G, Bhatt N, Richardson K, Noonan FP
QTL for ethanol conditioned taste aversion on Chr17 at D17Ncvs39 (23.83 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 0.00 - 48.83 Mbp (NCBI Build 37) on Chr17. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with cocaine induced activation 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (47859524)
QTL associated with antibody response to human factor IX. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33874679)
QTL associated with P. chabaudi malaria resistance QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34380179)
Authors:
Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, Foote S, Gros P
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