GeneSet Information

Tier II GS135455 • body weight 2 (Bodwt2, Published QTL Chr 17)

DESCRIPTION:

QTL associated with body weight 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (51571276)

LABEL:

QTL-Bodwt2-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Su Z, Li Y, James JC, Matsumoto AH, Helm GA, Lusis AJ, Shi W

TITLE:

Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice.

JOURNAL:

Human molecular genetics May 2006, Vol 15, pp. 1650-8

ABSTRACT:

Dyslipidemia and hyperglycemia are integral components of the metabolic perturbations in type 2 diabetes. Apolipoprotein E-deficient (apoE(-/-)) mice develop severe hyperlipidemia and significant hyperglycemia when fed a western diet containing 21% fat (w/w), 0.15% cholesterol and 19.5% casein. Using an intercross between C57BL/6J (B6) and C3H/HeJ (C3H) apoE(-/-) mice, we performed quantitative trait locus (QTL) analysis to identify loci contributing to hyperglycemia and associated traits. Fasting plasma levels of glucose, insulin and serum amyloid-P (SAP) and body weight in 234 female F2 mice were measured after being fed the western diet for 12 weeks. QTL analysis revealed one significant QTL, named Bglu3 [95.8 cM, logarithm of odds ratio (OR)(LOD) 4.1], on chromosome 1 and a suggestive QTL on chromosome 9 (38 cM, LOD 2.3) that influenced plasma glucose levels. Bglu3 coincided with loci on distal chromosomal 1 that had a major influence on plasma SAP levels and body weight. Significant correlations between plasma glucose, SAP and body weight were observed in F2 mice. Thus, these results demonstrate genetic linkages of hyperglycemia and body weight with SAP, a marker of the acute-phase response, in hyperlipidemic apoE(-/-) mice and suggest a probability for the Sap gene to be a positional candidate of Bglu3. PUBMED: 16595606
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Annotation Information

No sequence read archive data associated with this GeneSet.


Chromosomes, Human, Pair 9 (D002899)
Glucose (D005947)
Fasting (D005215)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Genetic Linkage (D008040)
Quantitative Trait Loci (D040641)
Odds Ratio (D016017)
Acute-Phase Reaction (D000210)
Cholesterol (D002784)
Insulin (D007328)
Caseins (D002364)
Dyslipidemias (D050171)
Apolipoproteins (D001053)
Probability (D011336)
Body Weight (D001835)
Hyperglycemia (D006943)
Hyperlipidemias (D006949)
adipose tissue (MA:0000009)
hyperlipidemia (MP:0001548)
hyperglycemia (MP:0001559)
acute-phase response (GO:0006953)
chromosome (GO:0005694)

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