DESCRIPTION:

QTL associated with cerebral malaria susceptibility in CBA/N. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34137861)

LABEL:

QTL-Cmcs-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3522313

AUTHORS:

Ohno T, Nishimura M

TITLE:

Detection of a new cerebral malaria susceptibility locus, using CBA mice.

JOURNAL:

Immunogenetics Dec 2004, Vol 56, pp. 675-8

ABSTRACT:

Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible locus in CBA mice was mapped to H2 region on Chromosome 17, tentatively designated cmsc. cmsc was mapped to a different chromosomal region from that previously reported in the C57BL/6 mouse model of CM. It is possible that different loci contribute to CM in CBA and C57BL/6 mouse strains. Comparison of the function of CM susceptibility loci between CBA and C57BL/6 mice could have important implications for the study of the complex pathogenesis of CM in humans. PUBMED: 15536567
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