GeneSet Information

Tier II GS135644 • cerebral malaria susceptibility in CBA/N (Cmcs, Published QTL Chr 17)

DESCRIPTION:

QTL associated with cerebral malaria susceptibility in CBA/N. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34137861)

LABEL:

QTL-Cmcs-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Ohno T, Nishimura M

TITLE:

Detection of a new cerebral malaria susceptibility locus, using CBA mice.

JOURNAL:

Immunogenetics Dec 2004, Vol 56, pp. 675-8

ABSTRACT:

Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible locus in CBA mice was mapped to H2 region on Chromosome 17, tentatively designated cmsc. cmsc was mapped to a different chromosomal region from that previously reported in the C57BL/6 mouse model of CM. It is possible that different loci contribute to CM in CBA and C57BL/6 mouse strains. Comparison of the function of CM susceptibility loci between CBA and C57BL/6 mice could have important implications for the study of the complex pathogenesis of CM in humans. PUBMED: 15536567
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Annotation Information



Mice, Inbred CBA (D008808)
Chromosomes (D002875)
Malaria (D008288)
Chromosomes, Human, Pair 17 (D002886)
Models, Theoretical (D008962)
Malaria, Cerebral (D016779)
Infection (D007239)
Plasmodium (D010961)
Plasmodium falciparum (D010963)
pathogenesis (GO:0009405)
chromosome (GO:0005694)

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