DESCRIPTION:

QTL associated with insulin dependent diabetes susceptibility 16. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33737692)

LABEL:

QTL-Idd16-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:107544

AUTHORS:

Deruytter N, Boulard O, Garchon HJ

TITLE:

Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.

JOURNAL:

Diabetes Dec 2004, Vol 53, pp. 3323-7

ABSTRACT:

Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes. PUBMED: 15561967
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