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QTL for morphine antinociception on Chr10 at D10Mit51 (19.52 Mbp , Build 37)
Description:
morphine antinociception spans 0.00 - 44.52 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Helms ML, O\'Toole LA, Jarvis MW, Hain HS, Mogil JS, Belknap JK
QTL for morphine preference on Chr10 at D10MIT282 (24.33 Mbp , Build 37)
Description:
morphine preference spans 0.00 - 49.33 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH
QTL associated with amphetamine distance traveled 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20654078)
Authors:
Torkamanzehi A, Boksa P, Ayoubi M, Fortier ME, Ng Ying Kin NM, Skamene E, Rouleau G, Joober R
QTL associated with atherosclerotic lesion area 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21435099)
QTL associated with atherosclerotic lesion area 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (18526522)
QTL associated with experimental allergic encephalomyelitis susceptibility 15. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21252061)
QTL associated with myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (28871992)
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with postnatal body weight growth 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21435099)
QTL associated with proteoglycan induced arthritis 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20654078)
Authors:
Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K
QTL associated with susceptibility to lung cancer 29. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (9133173)
QTL associated with SGC/Knj cross B6 QTL 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (28871992)
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with voluntary alcohol consumption QTL 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (11362694)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler