DESCRIPTION:

morphine preference spans 0.00 - 49.33 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).

LABEL:

QTL for morphine preference on Chr10 at D10MIT282 (24.33 Mbp , Build 37)

SCORE TYPE:

Binary

DATE ADDED:

2010-10-01

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH

TITLE:

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.

JOURNAL:

Nature genetics May 1994, Vol 7, pp. 54-8

ABSTRACT:

Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains. PUBMED: 8075641
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