GeneSet Information

Tier II GS135342 • atherosclerosis 20 (Ath20, Published QTL Chr 10)

DESCRIPTION:

QTL associated with atherosclerosis 20. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20127245)

LABEL:

QTL-Ath20-Mouse-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B

TITLE:

Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvImJ.

JOURNAL:

Arteriosclerosis, thrombosis, and vascular biology Jan 2004, Vol 24, pp. 161-6

ABSTRACT:

The C57BL/6 (B6) and 129 mouse inbred strains differ markedly in plasma HDL-cholesterol concentrations and atherosclerosis susceptibility after a high-fat diet consumption. To identify loci controlling these traits, we performed quantitative trait loci (QTL) analysis.We fed a high-fat diet to 294 (B6x129S1/SvImJ)F2 females for 14 weeks, measured plasma HDL concentrations and size of aortic fatty-streak lesions, genotyped F2 females, and performed QTL analysis. HDL concentrations were affected by six loci: Hdlq14 and Hdlq15 on chromosome 1 (peaks cM 80 and cM 104, logarithm of odds [LOD] 5.3 and 9.7, respectively); Hdlq16 on chromosome 8 (cM 44, LOD 2.6); Hdlq17 on chromosome 9 (cM 24, LOD 2.9); Hdlq18 on chromosome 12 (cM 20, LOD 5.9); and Hdlq19 on chromosome 2 (cM 90), which interacted with Hdlq15. Atherosclerosis susceptibility was affected by five loci: Ath17 on chromosome 10 (cM 34, LOD 6.6); Ath18 on chromosome 12 (cM 16, LOD 3.7); Ath19 (chromosome 11, cM 60), which interacted with Ath18; and Ath20 (chromosome 10, cM 10), which interacted with Ath21 (chromosome 12, cM 50).We identified six loci for HDL and five loci for atherosclerosis susceptibility in a (B6x129S1/SvImJ)F2 intercross. PUBMED: 14592847
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Annotation Information



Chromosomes, Human, Pair 8 (D002898)
Chromosomes, Human, Pair 9 (D002899)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Chromosomes, Human, Pair 10 (D002879)
Quantitative Trait Loci (D040641)
Chromosomes, Human, Pair 2 (D002889)
Chromosomes, Human, Pair 12 (D002881)
Attention (D001288)
Mice, 129 Strain (D057507)
Mice, Inbred Strains (D008815)
Atherosclerosis (D050197)
atherosclerotic lesions (MP:0005338)
chromosome (GO:0005694)

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