Cerebellum Gene Expression Correlates for COCA_TIME_COND_CHG measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The COCA_TIME_COND_CHG measures Cocaine CPP - difference in time spent relative to baseline drug exposure under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for COCA_TIME_PCT_CHANGE measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The COCA_TIME_PCT_CHANGE measures Cocaine CPP - difference in percent test time spent relative to preconditioning under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for SPD_TIMEDOWELBSEC measured in BXD RI Females & Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The SPD_TIMEDOWELBSEC measures Dowel Test - Time B Sec under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for ethanol withdrawal on Chr15 at D15Ncvs19 (0.00 Mbp , Build 37)
Description:
ethanol withdrawal spans 0.00 - 25.00 Mbp (NCBI Build 37) on Chr15. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for high-dose ethanol actions on Chr15 at D15Mit12 (12.77 Mbp , Build 37)
Description:
high-dose ethanol actions spans 0.00 - 37.77 Mbp (NCBI Build 37) on Chr15. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
Acute and chronic alcohol exposure was analyzed in 534 (C57BL/6J x C3H/HeJ)F2 mice. Behavioral testing was done using 5 traits, acute drug effect, forced ethanol drinking, withdrawal studies ethanol preference and stress induced ethanol drinking. The following QTL were found in a genome wide scan: Following the QTL is the Chromosome , cM location, and LOD score, Eih1 (Chr 1, 85 cM, LOD 6.6), Eih2 (Chr 7, 10 cM, LOD 3.6), Ceih1 (Chr 3, 55 cM, LOD 4.1), Ceih2 (Chr 6, 24.7 cM, LOD 4.1), Ceih3 (Chr 13, 39 cM, LOD 4.1), Eia1(Chr 1, 65 cM, LOD 10.3 and 10.4), Eiwa1 (Chr 7, 50 cM, LOD 4.4), Eiwa2(Chr 11, 43.1 cM, LOD 4.1),Aldd1(Chr 5, 42 cM, LOD 13.2), Aldd2(Chr 12, 18 cM, LOD 5.3),Eiwax1(Chr 1, 79 cM, LOD 6.5), Eiwax2(Chr 5, 59 cM, LOD 15.0), Eiwax3(Chr 12, 21 cM, LOD 3.6), Methp1(Chr 16, 31.4 cM, LOD 4.3), Mec1(Chr 16, 19.4 cM, LOD 5.1), Epbs1(Chr 16, 33 cM, LOD 4.1), Ecbs1(Chr 16, 29.4 cM, LOD 4.8), Mec2(Chr 1, 109 cM, LOD 3.9), Mec3(Chr 2, 109 cM, LOD 4.3), Mec4(Chr 5, 29 cM, LOD 3.9), Mec5(Chr 10, 2 cM, LOD 5.0), Mec6(Chr 15, 49 cM, LOD 5.2, 95% CI 6.7–56.7).
Authors:
Drews E, Rcz I, Lacava AD, Barth A, Bilkei-Gorz A, Wienker TF, Zimmer A
Linkage analysis was performed on a series of Recombinant QTL Introgression (RQI) strains (derived from C57BL/6ByJ and BALB/cJ) to identify QTLs associated with alcohol preference. Male animals from each of 13 RQI strains were tested for 12% alcohol preference and genotyped at 244 polymorphic loci with an average spacing of 6.6 cM. Progenitor strain C57BL/6ByJ exhibits higher alcohol preference than progenitor strain BALB/cJ. Significant linkage to 12% alcohol preference (P<0.0002) mapped to a region of mouse Chromosome 15 spanning markers D15Mit159 (49.6 cM), D15Mit34 (52.2 cM), and D15Mit242 (55.6 cM). The experiment was done in duplicate and the same 3 chromosome 15 markers were detected each time. This locus is named Alprf (alcohol preference.) BALB/cJ-derived alleles confer increased alcohol preference at this locus. Potential candidate genes mapping near Alprf include Ecgf1 (51.6 cM), Cntn1 (55.1 cM), Kif21a (55.1 cM), Pou6f1 (56.6 cM), and Aqp5 (56.8 cM).
Authors:
Vadasz C, Saito M, Balla A, Kiraly I, Vadasz C 2nd, Gyetvai B, Mikics E, Pierson D, Brown D, Nelson JC
Ethanol Preference from BXD lines span 58586243-108586243. This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Marker Loci associated with 10% Ethanol Preferences Drinking at p<0.05 (Two Tailed) in the BXD RI set and the Correlation Coefficient, p and Estimated LOD. D15Mit33 (83586243 NCBI 37) p=0.05, LOD=0.08 overall LOD BXD & Select Line 2.4.
QTL for Voluntary Ethanol Consumption on LS x SS RI lines spans 43765164-93765164 .This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Chr 15 D15Mit3 39 cM VEC (females) 0.02
In the present study Aaq1, a previously mapped QTL on mouse Chromosome 15 linked to alcohol acceptance, is confirmed using a (C57BL/6J x DBA/2J)F2 population. Aaq1 mapped to 15 cM (D15Mit60)- 48 cM (D15Mit34) on mouse Chromosome 15 with a peak LOD score of 3.8 at approximately 30 cM. C57BL/6J-derived alleles confer increased alcohol acceptance in a dominant fashion at Aaq1. A potential candidate gene for Aaq1 is the peripheral benzodiazepine receptor gene, Bzrp.
Authors:
McClearn GE, Tarantino LM, Rodriguez LA, Jones BC, Blizard DA, Plomin R
QTL mapping results for B6D2F2 mice in regions provisionally identified in BXD RI mice for free-choice ethanol consumption. Peak D15Mit33 58586243-108586243. This interval was obtained by using an arbitrary interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org)
QTL associated with absorbance of eye lens protein. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (89887788)
Authors:
Wisser KC, Schauerte JA, Burke DT, Galecki A, Chen S, Miller RA, Gafni A
QTL associated with bleomycin-induced pulmonary fibrosis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (93461597)
QTL associated with collagen induced arthritis 35. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (81758055)
QTL associated with collagen induced arthritis 37. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (97817483)
QTL associated with cocaine related behavior 14. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (68765096)
QTL associated with directional asymmetry QTL 14. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (68969216)
Authors:
Kosarov M, Havelkov H, Krulov M, Demant P, Lipoldov M
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