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GS115118 • A QTL region for alcohol preference
Marker Hoxc at 48cM. Mapped 48cM onto current genome to get peak marker then took 25 Mbp interval. 68944502-118944502
Alcohol Preference Chr 15
Tarantino LM, McClearn GE, Rodriguez LA, Plomin R
Confirmation of quantitative trait loci for alcohol preference in mice.
Alcoholism, clinical and experimental research
Vol 22, pp. 1099-105
An F2 intercross derived from C57BL/6 and DBA/2 progenitor inbred strains was used to test for replication of quantitative trait loci (QTLs) for alcohol preference nominated by a previous study using BXD recombinant inbred (RI) strains (Rodriguez et al., Alcohol. Clin. Exp. Res. 19:367-379, 1995). Fourteen provisional QTLs were nominated in the original RI study with a p < 0.05 criterion. In the present study, a genome scan (101 microsatellite markers) was conducted on an F2 population (n = 218). Three significant QTLs were detected on chromosomes 1, 4, and 9, and three suggestive QTLs were detected on chromosomes 2, 3, and 10. Of these six QTLs, four were consistent with the previous RI nominations. The replication rate of 28.6% (4 of 14) is in agreement with the results of simulation studies performed by Belknap et al. (Behav. Genet. 26:149-160, 1996) and supports the methodological argument for a multistage research design for nominating and replicating QTLs.
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