DESCRIPTION:

QTL associated with brachyury modifier 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (82471605)

LABEL:

QTL-Brm2-Mouse-Chr 15

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1201376

AUTHORS:

Agulnik II, Agulnik SI, Saatkamp BD, Silver LM

TITLE:

Sex-specific modifiers of tail development in mice heterozygous for the brachyury (T) mutation.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Feb 1998, Vol 9, pp. 107-10

ABSTRACT:

The brachyury, or T, locus encodes a transcription factor that plays a crucial role in the early development of all animals. In the mouse, animals heterozygous for a null mutation at this locus are born with a characteristic short tail. Expressivity of the short tail phenotype is greatly affected by genetic background. As a genetic entry into the identification of genes that interact with the Brachyury locus, we have performed a QTL analysis for modifiers of this phenotype. Surprisingly, we discovered that the major modifiers uncovered all act in a sex-limited manner. We have identified two QTLs--Brm1 on Chr 9 and Brm2 on Chr 15--that act only in female offspring(N2) from female T/+ parents(F1) and are responsible together for most, or all, of the genetic variance in phenotypic expression observed between C57BL/10 and C3H/HeJ animals. PUBMED: 9457669
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