QTL associated with behavioral response to methamphetamines 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (36137026)
QTL associated with dystrophic cardiac calcinosis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (30304100)
QTL associated with insulin dependent diabetes susceptibility 12. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35170432)
QTL associated with insulin dependent diabetes susceptibility 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21656627)
QTL associated with modifier of ocular retardation 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25745310)
QTL associated with resistance to thymic deletion 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (13403047)
Authors:
Liston A, Lesage S, Gray DH, O\'Reilly LA, Strasser A, Fahrer AM, Boyd RL, Wilson J, Baxter AG, Gallo EM, Crabtree GR, Peng K, Wilson SR, Goodnow CC
QTL associated with susceptibility to lung cancer 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (36918833)
QTL associated with Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (36137026)
Authors:
Bureau JF, Drescher KM, Pease LR, Vikoren T, Delcroix M, Zoecklein L, Brahic M, Rodriguez M
QTL associated with white blood cell quantitative locus 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (17356225)
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
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