DESCRIPTION:

QTL associated with modifier of ocular retardation 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25745310)

LABEL:

QTL-Modor2-Mouse-Chr 14

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3656498

AUTHORS:

Wong G, Conger SB, Burmeister M

TITLE:

Mapping of genetic modifiers affecting the eye phenotype of ocular retardation (Chx10or-J) mice.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Jun 2006, Vol 17, pp. 518-25

ABSTRACT:

Ocular retardation is a recessive murine mutation whose phenotypic expression is greatly affected by genetic background effects. Mice of the inbred 129/SvJ background that are homozygous for the Chx10(or-J) mutation are blind and have a thin, poorly differentiated retina and no optic nerve. A backcross between 129/SvJ and Mus musculus castaneus (CASA/Rk) produced animals that were homozygous for the Chx10(or-J) mutation, yet showed a much milder phenotype. Such animals, when brother-sister mated and selected for mild phenotype for several generations, resulted in partial recovery of visual function, including presence of an optic nerve and pupillary response. In this article we report a genome scan of phenotypic extremes of the backcross to identify the genetic loci affecting this phenotype modification. Our scan revealed significant loci on Chromosomes 6 and 14 where the CASA/Rk alleles are maintained selectively. Markers were developed near candidate genes, but no candidate gene could be identified unequivocally. PUBMED: 16783634
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