DESCRIPTION:

QTL associated with insulin dependent diabetes susceptibility 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21656627)

LABEL:

QTL-Idd8-Mouse-Chr 14

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:96410

AUTHORS:

Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall RJ, Prins JB, McShane P, Lathrop GM, Peterson LB

TITLE:

Polygenic control of autoimmune diabetes in nonobese diabetic mice.

JOURNAL:

Nature genetics Aug 1993, Vol 4, pp. 404-9

ABSTRACT:

Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to diabetes or the prediabetic lesion, insulitis, indicative of a polygenic mode of inheritance. The relative importance of these loci and their interactions have been assessed using a new application of multiple polychotomous regression methods. A candidate disease gene, interleukin-2 (Il-2), which is closely linked to insulitis and diabetes, is shown to have a different sequence in NOD, including an insertion and a deletion of tandem repeat sequences which encode amino acid repeats in the mature protein. PUBMED: 8401590
Find other GeneSets from this publication