DESCRIPTION:

QTL associated with Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (36137026)

LABEL:

QTL-Tmevd3-Mouse-Chr 14

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1289246

AUTHORS:

Bureau JF, Drescher KM, Pease LR, Vikoren T, Delcroix M, Zoecklein L, Brahic M, Rodriguez M

TITLE:

Chromosome 14 contains determinants that regulate susceptibility to Theiler\'s virus-induced demyelination in the mouse.

JOURNAL:

Genetics Apr 1998, Vol 148, pp. 1941-9

ABSTRACT:

Theiler\'s murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex-linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA/2J x B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination. PUBMED: 9560407
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