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List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Night sleep phenotypes. The EFO term sleep quality was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Spada, M Scholz, H Kirsten, T Hensch, K Horn, P Jawinski, C Ulke, R Burkhardt, K Wirkner, M Loeffler, U Hegerl, C Sander
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Whole brain expression correlates of ethanol withdrawal in BXD RI mice based on phenotype data in the 1997 Buck et al manuscript. Expression correlates were generated using GeneNetwork.org
Striatum Gene Expression Correlates for LM_CUE_ACTIVITY measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The LM_CUE_ACTIVITY measures Activity in altered context during presentation of cue under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for LM_CUE_SUPPRESS measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The LM_CUE_SUPPRESS measures Suppression of activity in altered context under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for NEPCOUNT15 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT15 measures Novel environment vertical activity counts minutes 0-15 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for NEPCOUNT15 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT15 measures Novel environment vertical activity counts minutes 0-15 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Striatum Gene Expression Correlates for ST_BACKGROUND measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_BACKGROUND measures Background startle response under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_MAX_70 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_MAX_70 measures Maximum startle response to 70 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_MAX_80 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_MAX_80 measures Maximum startle response to 80 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_MAX_85 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_MAX_85 measures Maximum startle response to 85 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for ST_MAX_85 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_MAX_85 measures Maximum startle response to 85 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for ZM_TCLOSED measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The ZM_TCLOSED measures Zero Maze - Time in Closed Arms under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for ZM_TOPEN measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The ZM_TOPEN measures Zero Maze - total time in open quadrants under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Comparison of mean signals and standard deviation (sdv) of genes which were recently described as predictive for lymphatic metastasis in colorectal carcinomas [12], between 31 amplified RNA samples of colon carcinomas and 24 RNA samples of colon carcinomas not amplified prior to microarray hybridization.
Authors:
Croner RS, Lausen B, Schellerer V, Zeittraeger I, Wein A, Schildberg C, Papadopoulos T, Dimmler A, Hahn EG, Hohenberger W, Brueckl WM
cocaine related behavior 3 (Cocrb3) spans 114.482445 - 164.482445 Mbp (NCBI Build 37) on Chr 2. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for activity response to ethanol on Chr2 at NA (129.21 Mbp , Build 37)
Description:
activity response to ethanol spans 104.21 - 154.21 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for cocaine related behavior on Chr2 at D2Byu3 (139.48 Mbp , Build 37)
Description:
cocaine related behavior spans 114.48 - 164.48 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol induced locomotion on Chr2 at NA (141.12 Mbp , Build 37)
Description:
ethanol induced locomotion spans 116.12 - 166.12 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr
Genes associated with Homo sapiens that interact with the MeSH term 'cobaltous chloride' (C018021). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Cyclosporine' (D016572). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Acetaldehyde' (D000079). Incorporates data from 7 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Valproic Acid' (D014635). Incorporates data from 1238 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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