GeneSet Information

Tier II GS84136 • ethanol induced locomotion (Published QTL, Chr 2)

DESCRIPTION:

ethanol induced locomotion spans 116.12 - 166.12 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).

LABEL:

QTL for ethanol induced locomotion on Chr2 at NA (141.12 Mbp , Build 37)

SCORE TYPE:

Binary

DATE ADDED:

2010-10-01

DATE UPDATED:

2019-01-07

SPECIES:

AUTHORS:

Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr

TITLE:

Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs.

JOURNAL:

Pharmacology, biochemistry, and behavior Dec 2000, Vol 67, pp. 767-72

ABSTRACT:

A genome-wide scan was conducted in two F(2) intercrosses, C57BL/6J (B6)xDBA/2J (D2) and BALB/cJ (C)xLP/J (LP), for three different phenotypes: basal locomotor activity, ethanol-induced locomotor activity, and haloperidol-induced catalepsy. For basal activity, significant quantitative trait loci (QTLs, LOD> or =4.3) were detected on chromosomes 9 and 19 for the CxLP intercross and chromosome 1 for the B6xD2 intercross. Significant QTLs for ethanol-induced activation were detected on chromosome 6 for the CxLP intercross, and on chromosomes 1 and 2 for the B6xD2 intercross. For haloperidol-induced catalepsy, significant QTLs were detected on chromosome 14 (two different QTLs) in the CxLP intercross, and chromosomes 1 and 9 in the B6xD2 intercross. These data illustrate the importance of the genetic cross for QTL detection. Finally, the data reported here, and elsewhere, are also used to demonstrate a novel approach to QTL detection and localization. PUBMED: 11166067
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Annotation Information



Catalepsy (D002375)
Chromosomes, Human, Pair 6 (D002896)
Crosses, Genetic (D003433)
Motor Activity (D009043)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Quantitative Trait Loci (D040641)
Chromosomes, Human, Pair 14 (D002883)
Informatics (D048088)
Locomotion (D008124)
Ethanol (D000431)
catalepsy (MP:0002822)
locomotion (GO:0040011)
localization (GO:0051179)
chromosome (GO:0005694)

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