GeneSet Information

Tier IV GS430 • EthanolWithdrawal


Whole brain expression correlates of ethanol withdrawal in BXD RI mice based on phenotype data in the 1997 Buck et al manuscript. Expression correlates were generated using











Buck KJ, Metten P, Belknap JK, Crabbe JC


Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.


The Journal of neuroscience : the official journal of the Society for Neuroscience May 1997, Vol 17, pp. 3946-55


Alcohol dependence (alcoholism) is accompanied by evidence of tolerance, withdrawal (physiological dependence), or compulsive behavior related to alcohol use. Studies of strain and individual differences using animal models for acute physiological dependence liability are useful means to identify potential genetic determinants of liability in humans. Behavioral and quantitative trait analyses were conducted using animal models for high risk versus resistance to acute physiological dependence. Using a two-step genetic mapping strategy, loci on mouse chromosomes 1, 4, and 11 were mapped that contain genes that influence alcohol withdrawal severity. In the aggregate, these three risk markers accounted for 68% of the genetic variability in alcohol withdrawal. Candidate genes in proximity to the chromosome 11 locus include genes encoding the alpha1, alpha6, and gamma2 subunits of type-A receptors for the inhibitory neurotransmitter, GABA. In addition, suggestive linkage is indicated for two loci on mouse chromosome 2, one near Gad1 encoding glutamic acid decarboxylase, and the other near the El2 locus which influences the seizure phenotype in the neurological mutant strain El. The present analyses detect and map some of the loci that increase risk to develop physiological dependence and may facilitate identification of genes related to the development of alcoholism. Syntenic conservation between human and mouse chromosomes suggests that human homologs of genes that increase risk for physiological dependence may localize to 1q21-q32, 2q24-q37/11p13, 9p21-p23/1p32-p22.1, and 5q32-q35. PUBMED: 9133412
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Annotation Information

Seizures (D012640)
Animals (D000818)
Individuality (D007206)
Behavior (D001519)
Chromosome Mapping (D002874)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
gamma-Aminobutyric Acid (D005680)
Synteny (D026801)
Models, Animal (D023421)
Genetic Predisposition to Disease (D020022)
Chromosomes, Human, Pair 2 (D002889)
Chromosomes, Human, Pair 11 (D002880)
Substance Withdrawal Syndrome (D013375)
Mice, Inbred C57BL (D008810)
Mice, Inbred DBA (D008811)
Brain Chemistry (D001923)
Compulsive Behavior (D003192)
Acute Disease (D000208)
Receptors, GABA (D018079)
Identification (Psychology) (D007062)
Neurotransmitter Agents (D018377)
Glutamate Decarboxylase (D005968)
Glutamic Acid (D018698)
Alcoholism (D000437)
Ethanol (D000431)
chromosome (GO:0005694)

Gene List • 430 Genes

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