Whole Brain Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Whole Brain Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Hippocampus Gene Expression Correlates for ADUL_RMS_BRDU measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The ADUL_RMS_BRDU measures Neurogenesis- BrdU labeled new neurons in Adult Rostral Migratory Stream 1 hr post BrdU under the domain Neurogenesis. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL associated with bone response to mechanical loading 12. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (3645155)
QTL associated with fluctuating asymmetry QTL 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20420342)
Authors:
Zhang S, Lou Y, Amstein TM, Anyango M, Mohibullah N, Osoti A, Stancliffe D, King R, Iraqi F, Gershenfeld HK
QTL associated with induction of brown adipocytes 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (26402805)
QTL associated with macrophage-associated risk inflammatory factor 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20636654)
QTL associated with nerve sheath tumor resistance QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (5321112)
Authors:
Walrath JC, Fox K, Truffer E, Gregory Alvord W, Quiones OA, Reilly KM
QTL associated with pulmonary adenoma susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20420342)
QTL associated with postnatal body weight growth 20. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (5011610)
QTL associated with tibia bone quality traits 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (15599162)
Authors:
Jiao Y, Chiu H, Fan Z, Jiao F, Eckstein EC, Beamer WG, Gu W
QTL associated with thymic lymphoma resistance 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (26884543)
Authors:
Santos J, Gonzlez-Snchez L, Villa-Morales M, Ors I, Lpez-Nieva P, Vaquero C, Gonzlez-Gugel E, Fernndez-Navarro P, Roncero AM, Guenet JL, Montagutelli X, Fernndez-Piqueras J
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
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