DESCRIPTION:

QTL associated with thymic lymphoma resistance 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (26884543)

LABEL:

QTL-Tlyr1-Mouse-Chr 19

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2651474

AUTHORS:

Santos J, Gonzlez-Snchez L, Villa-Morales M, Ors I, Lpez-Nieva P, Vaquero C, Gonzlez-Gugel E, Fernndez-Navarro P, Roncero AM, Guenet JL, Montagutelli X, Fernndez-Piqueras J

TITLE:

The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with -radiation-induced T-cell lymphoblastic lymphomas.

JOURNAL:

Oncogene Sep 2010, Vol 29, pp. 5265-73

ABSTRACT:

Using an inter-specific subcongenic strain, Nested Recombinant Haplotype 3 (NRH3), generated between two mouse strains showing extreme differences in γ-radiation-induced thymic lymphoma susceptibility (SEG/Pas and C57BL/6J), we have identified a critical region on chromosome 19 that regulates survival of mice suffering from T-cell lymphoblastic lymphomas. Mapped on this region, the gene encoding the Cd274 ligand is able to trigger an inhibitory effect that modulates T-cell receptor (TCR) signalling and affects thymocyte maturation. Interestingly, this gene shows differential expression between thymic stromal cells from both strains in early response to a single sublethal γ-ray dose, but is inhibited in T-cell lymphoblastic lymphomas. Furthermore, we have identified several polymorphisms in the complementary DNA sequence of this gene that affect the affinity for its Cd279 receptor and are able to induce a differential rate of thymocyte apoptosis. Taken together, our data are consistent with Cd274 acting as a genetic modifier that influences the survival of γ-radiation-induced T-cell lymphoma-bearing mice. The data similarly support the idea of a co-evolution of tumour cells and associated stromal cells to generate a favourable microenvironment for T-cell lymphoma growth. PUBMED: 20639904
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