The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
Ethanol Induced Ataxia Chr#17 rs3672987(33247165) with right flanking marker rs4136382(3388912) and left marker rs3715723(58810428). This was mapped in 300 + (b6x129)F2 mice.
QTL Associated with Consumption level. On Chromosome 17 with a LOD score= 11.4, p-value =0.001. From a(n) intercross of QTL Associated with Consumption level. On Chromosome 20 with a LOD score= 8, p-value =0.001. From a(n) intercross of
Authors:
Marissal-Arvy N, Diane A, Moisan MP, Larue-Achagiotis C, Tridon C, Tome D, Fromentin G, Mormède P
QTL Associated with Consumption level. On Chromosome 12 with a LOD score= 2.1, p-value =0.68. From a(n) of QTL Associated with Alcohol response. On Chromosome 20 with a LOD score= 3.2, p-value =0.05. From a(n) intercoss of
Authors:
Radcliffe RA, Erwin VG, Bludeau P, Deng X, Fay T, Floyd KL, Deitrich RA
QTL Associated with blood insulin amount. On Chromosome 17 with a LOD score= 8.82, p-value =0.001. From a(n) intercross of QTL Associated with blood insulin amount. On Chromosome 20 with a LOD score= 6.38, p-value =0.001. From a(n) intercross of
Authors:
Marissal-Arvy N, Heliès JM, Tridon C, Moisan MP, Mormède P
Genes identified as expressed lower (down) in the AJ strain than in the CAST strain. Differentially expressed genes had a Q-value < 0.05 following the Benjamini-Hochberg methodology for false discovery rates in the limma+voom pipeline within edgeR. Q-value is reported from the topTable function.
Genes identified as expressed lower (down) in the AJ strain than in the WSB strain. Differentially expressed genes had a Q-value < 0.05 following the Benjamini-Hochberg methodology for false discovery rates in the limma+voom pipeline within edgeR. Q-value is reported from the topTable function.
Genes identified as expressed lower (down) in the AJ strain than in the CAST strain. Differentially expressed genes had a Q-value < 0.05 following the Benjamini-Hochberg methodology for false discovery rates in the limma+voom pipeline within edgeR. Q-value is reported from the topTable function.
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