DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 20 with a LOD score= , p-value =0.001. From a(n) intercross of

LABEL:

QTL-Bp144-Rat-Chr 20

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Otsen M, den Bieman M, Kuiper MT, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A, van Zutphen BF

TITLE:

Use of AFLP markers for gene mapping and QTL detection in the rat.

JOURNAL:

Genomics None None, Vol 37, pp. 289-94

ABSTRACT:

1. Genomics. 1996 Nov 1;37(3):289-94. Use of AFLP markers for gene mapping and QTL detection in the rat. Otsen M(1), den Bieman M, Kuiper MT, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A, van Zutphen BF. Author information: (1)Department of Laboratory Animal Science, Utrecht University, The Netherlands. The AFLP technique is a new DNA marker technology based on the selective amplification of restriction fragments. Multiple polymorphic markers are simultaneously produced and can be tested in one PCR. No prior information on genomic DNA sequences is needed. In the current study, we contribute 18 AFLP markers to the linkage map of the rat. Seven AFLP markers were assigned to specific chromosomes by analysis of a (BN x ACI)F1 x ACI backcross progeny. Another 11 AFLP markers were mapped by using a panel of the H x B/B x H recombinant inbred (RI) strains. Genotypes of these AFLP markers were also tested for correlations with some blood pressure phenotypes in the RI strains. Suggestive correlation was found between the mean arterial pressure and two closely linked AFLP markers located on chromosome 20. The current study illustrates the value of AFLP markers for the construction of linkage maps and the detection of quantitative trait loci. PMID: 8938440 [PubMed - indexed for MEDLINE] PUBMED: 8938440
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