List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits. The EFO term fasting blood glucose measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT Martínez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-Ríos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits. The EFO term HOMA-B was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT Martínez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-Ríos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Obesity. The EFO term obesity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
HJ Kim, YJ Yoo, YS Ju, S Lee, SI Cho, J Sung, JI Kim, JS Seo
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was HIV-1 progression. The EFO term HIV-1 infection was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JT Herbeck, GS Gottlieb, CA Winkler, GW Nelson, P An, BS Maust, KG Wong, JL Troyer, JJ Goedert, BD Kessing, R Detels, SM Wolinsky, J Martinson, S Buchbinder, GD Kirk, LP Jacobson, JB Margolick, RA Kaslow, SJ O'Brien, JI Mullins
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Mahajan, MJ Go, W Zhang, JE Below, KJ Gaulton, T Ferreira, M Horikoshi, AD Johnson, MC Ng, I Prokopenko, D Saleheen, X Wang, E Zeggini, GR Abecasis, LS Adair, P Almgren, M Atalay, T Aung, D Baldassarre, B Balkau, Y Bao, AH Barnett, I Barroso, A Basit, LF Been, J Beilby, GI Bell, R Benediktsson, RN Bergman, BO Boehm, E Boerwinkle, LL Bonnycastle, N Burtt, Q Cai, H Campbell, J Carey, S Cauchi, M Caulfield, JC Chan, LC Chang, TJ Chang, YC Chang, G Charpentier, CH Chen, H Chen, YT Chen, KS Chia, M Chidambaram, PS Chines, NH Cho, YM Cho, LM Chuang, FS Collins, MC Cornelis, DJ Couper, AT Crenshaw, RM van Dam, J Danesh, D Das, U de Faire, G Dedoussis, P Deloukas, AS Dimas, C Dina, AS Doney, PJ Donnelly, M Dorkhan, C van Duijn, J Dupuis, S Edkins, P Elliott, V Emilsson, R Erbel, JG Eriksson, J Escobedo, T Esko, E Eury, JC Florez, P Fontanillas, NG Forouhi, T Forsen, C Fox, RM Fraser, TM Frayling, P Froguel, P Frossard, Y Gao, K Gertow, C Gieger, B Gigante, H Grallert, GB Grant, LC Grrop, CJ Groves, E Grundberg, C Guiducci, A Hamsten, BG Han, K Hara, N Hassanali, AT Hattersley, C Hayward, AK Hedman, C Herder, A Hofman, OL Holmen, K Hovingh, AB Hreidarsson, C Hu, FB Hu, J Hui, SE Humphries, SE Hunt, DJ Hunter, K Hveem, ZI Hydrie, H Ikegami, T Illig, E Ingelsson, M Islam, B Isomaa, AU Jackson, T Jafar, A James, W Jia, KH Jöckel, A Jonsson, JB Jowett, T Kadowaki, HM Kang, S Kanoni, WH Kao, S Kathiresan, N Kato, P Katulanda, KM Keinanen-Kiukaanniemi, AM Kelly, H Khan, KT Khaw, CC Khor, HL Kim, S Kim, YJ Kim, L Kinnunen, N Klopp, A Kong, E Korpi-Hyövälti, S Kowlessur, P Kraft, J Kravic, MM Kristensen, S Krithika, A Kumar, J Kumate, J Kuusisto, SH Kwak, M Laakso, V Lagou, TA Lakka, C Langenberg, C Langford, R Lawrence, K Leander, JM Lee, NR Lee, M Li, X Li, Y Li, J Liang, S Liju, WY Lim, L Lind, CM Lindgren, E Lindholm, CT Liu, JJ Liu, S Lobbens, J Long, RJ Loos, W Lu, J Luan, V Lyssenko, RC Ma, S Maeda, R Mägi, S Männisto, DR Matthews, JB Meigs, O Melander, A Metspalu, J Meyer, G Mirza, E Mihailov, S Moebus, V Mohan, KL Mohlke, AD Morris, TW Mühleisen, M Müller-Nurasyid, B Musk, J Nakamura, E Nakashima, P Navarro, PK Ng, AC Nica, PM Nilsson, I Njølstad, MM Nöthen, K Ohnaka, TH Ong, KR Owen, CN Palmer, JS Pankow, KS Park, M Parkin, S Pechlivanis, NL Pedersen, L Peltonen, JR Perry, A Peters, JM Pinidiyapathirage, CG Platou, S Potter, JF Price, L Qi, V Radha, L Rallidis, A Rasheed, W Rathman, R Rauramaa, S Raychaudhuri, NW Rayner, SD Rees, E Rehnberg, S Ripatti, N Robertson, M Roden, EJ Rossin, I Rudan, D Rybin, TE Saaristo, V Salomaa, J Saltevo, M Samuel, DK Sanghera, J Saramies, J Scott, LJ Scott, RA Scott, AV Segrè, J Sehmi, B Sennblad, N Shah, S Shah, AS Shera, XO Shu, AR Shuldiner, G Sigurđsson, E Sijbrands, A Silveira, X Sim, S Sivapalaratnam, KS Small, WY So, A Stančáková, K Stefansson, G Steinbach, V Steinthorsdottir, K Stirrups, RJ Strawbridge, HM Stringham, Q Sun, C Suo, AC Syvänen, R Takayanagi, F Takeuchi, WT Tay, TM Teslovich, B Thorand, G Thorleifsson, U Thorsteinsdottir, E Tikkanen, J Trakalo, E Tremoli, MD Trip, FJ Tsai, T Tuomi, J Tuomilehto, AG Uitterlinden, A Valladares-Salgado, S Vedantam, F Veglia, BF Voight, C Wang, NJ Wareham, R Wennauer, AR Wickremasinghe, T Wilsgaard, JF Wilson, S Wiltshire, W Winckler, TY Wong, AR Wood, JY Wu, Y Wu, K Yamamoto, T Yamauchi, M Yang, L Yengo, M Yokota, R Young, D Zabaneh, F Zhang, R Zhang, W Zheng, PZ Zimmet, D Altshuler, DW Bowden, YS Cho, NJ Cox, M Cruz, CL Hanis, J Kooner, JY Lee, M Seielstad, YY Teo, M Boehnke, EJ Parra, JC Chambers, ES Tai, MI McCarthy, AP Morris
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits. The EFO term HOMA-IR was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT Martínez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-Ríos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits. The EFO term fasting blood insulin measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT Martínez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-Ríos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting insulin-related traits. The EFO term HOMA-IR, fasting blood insulin measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT Martínez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-Ríos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
GWAS: body mass index, fasting blood glucose measurement
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits (interaction with BMI). The EFO term body mass index, fasting blood glucose measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
AK Manning, MF Hivert, RA Scott, JL Grimsby, N Bouatia-Naji, H Chen, D Rybin, CT Liu, LF Bielak, I Prokopenko, N Amin, D Barnes, G Cadby, JJ Hottenga, E Ingelsson, AU Jackson, T Johnson, S Kanoni, C Ladenvall, V Lagou, J Lahti, C Lecoeur, Y Liu, MT Martinez-Larrad, ME Montasser, P Navarro, JR Perry, LJ Rasmussen-Torvik, P Salo, N Sattar, D Shungin, RJ Strawbridge, T Tanaka, CM van Duijn, P An, M de Andrade, JS Andrews, T Aspelund, M Atalay, Y Aulchenko, B Balkau, S Bandinelli, JS Beckmann, JP Beilby, C Bellis, RN Bergman, J Blangero, M Boban, M Boehnke, E Boerwinkle, LL Bonnycastle, DI Boomsma, IB Borecki, Y Böttcher, C Bouchard, E Brunner, D Budimir, H Campbell, O Carlson, PS Chines, R Clarke, FS Collins, A Corbatón-Anchuelo, D Couper, U de Faire, GV Dedoussis, P Deloukas, M Dimitriou, JM Egan, G Eiriksdottir, MR Erdos, JG Eriksson, E Eury, L Ferrucci, I Ford, NG Forouhi, CS Fox, MG Franzosi, PW Franks, TM Frayling, P Froguel, P Galan, E de Geus, B Gigante, NL Glazer, A Goel, L Groop, V Gudnason, G Hallmans, A Hamsten, O Hansson, TB Harris, C Hayward, S Heath, S Hercberg, AA Hicks, A Hingorani, A Hofman, J Hui, J Hung, MR Jarvelin, MA Jhun, PC Johnson, JW Jukema, A Jula, WH Kao, J Kaprio, SL Kardia, S Keinanen-Kiukaanniemi, M Kivimaki, I Kolcic, P Kovacs, M Kumari, J Kuusisto, KO Kyvik, M Laakso, T Lakka, L Lannfelt, GM Lathrop, LJ Launer, K Leander, G Li, L Lind, J Lindstrom, S Lobbens, RJ Loos, J Luan, V Lyssenko, R Mägi, PK Magnusson, M Marmot, P Meneton, KL Mohlke, V Mooser, MA Morken, I Miljkovic, N Narisu, J O'Connell, KK Ong, BA Oostra, LJ Palmer, A Palotie, JS Pankow, JF Peden, NL Pedersen, M Pehlic, L Peltonen, B Penninx, M Pericic, M Perola, L Perusse, PA Peyser, O Polasek, PP Pramstaller, MA Province, K Räikkönen, R Rauramaa, E Rehnberg, K Rice, JI Rotter, I Rudan, A Ruokonen, T Saaristo, M Sabater-Lleal, V Salomaa, DB Savage, R Saxena, P Schwarz, U Seedorf, B Sennblad, M Serrano-Rios, AR Shuldiner, EJ Sijbrands, DS Siscovick, JH Smit, KS Small, NL Smith, AV Smith, A Stančáková, K Stirrups, M Stumvoll, YV Sun, AJ Swift, A Tönjes, J Tuomilehto, S Trompet, AG Uitterlinden, M Uusitupa, M Vikström, V Vitart, MC Vohl, BF Voight, P Vollenweider, G Waeber, DM Waterworth, H Watkins, E Wheeler, E Widen, SH Wild, SM Willems, G Willemsen, JF Wilson, JC Witteman, AF Wright, H Yaghootkar, D Zelenika, T Zemunik, L Zgaga, NJ Wareham, MI McCarthy, I Barroso, RM Watanabe, JC Florez, J Dupuis, JB Meigs, C Langenberg
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Opioid use disorder_human_dorsolateral prefrontal cortex_coefficient
Description:
RNA sequencing on the dorsolateral prefrontal cortex (DLPFC) and nucleus accumbens (NAc) from unaffected comparison subjects (n = 20) and subjects diagnosed with opioid use disorder OUD (n = 20). Transcriptomic analyses identified differentially expressed transcripts and investigated the transcriptional coherence between brain regions using rank-rank hypergeometric orderlap.transcriptional differences by brain region in unaffected comparison subjects, finding unique transcriptional profiles in the DLPFC and NAc
Authors:
Marianne L Seney, Sam-Moon Kim, Jill R Glausier, Mariah A Hildebrand, Xiangning Xue, Wei Zong, Jiebiao Wang, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Zachary Freyberg, Ryan W Logan
Opioid use disorder_human_nucleus accumbens_coefficient
Description:
RNA sequencing on the dorsolateral prefrontal cortex (DLPFC) and nucleus accumbens (NAc) from unaffected comparison subjects (n = 20) and subjects diagnosed with opioid use disorder OUD (n = 20). Transcriptomic analyses identified differentially expressed transcripts and investigated the transcriptional coherence between brain regions using rank-rank hypergeometric orderlap.transcriptional differences by brain region in unaffected comparison subjects, finding unique transcriptional profiles in the DLPFC and NAc
Authors:
Marianne L Seney, Sam-Moon Kim, Jill R Glausier, Mariah A Hildebrand, Xiangning Xue, Wei Zong, Jiebiao Wang, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Zachary Freyberg, Ryan W Logan
Striatum Gene Expression Correlates for ROTAETHA_TIME measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ROTAETHA_TIME measures Mean time on rotarod following ethanol under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMCNT165 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMCNT165 measures Morphine photocell counts minutes 150-165 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMCNT180 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMCNT180 measures Morphine photocell counts minutes 165-180 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for URINE measured in BXD RI Females & Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The URINE measures Novel Open Field Number of urinations under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VERCNT15 measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VERCNT15 measures Morphine vertical activity counts minutes 0-15 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VERCNT30 measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VERCNT30 measures Morphine vertical activity counts minutes 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
cocaine related behavior 2 (Cocrb2) spans 144.050573 - 194.050573 Mbp (NCBI Build 37) on Chr 1. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for ethanol conditioned taste aversion on Chr1 at NA (167.59 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 142.59 - 192.59 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for cocaine related behavior on Chr1 at D1Ncvs12 (169.05 Mbp , Build 37)
Description:
cocaine related behavior spans 144.05 - 194.05 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for climbing on Chr1 at D1Ncvs12 (169.05 Mbp , Build 37)
Description:
METH responses for climbing spans 144.05 - 194.05 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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