DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits (interaction with BMI). The EFO term body mass index, fasting blood glucose measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index, fasting blood glucose measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AK Manning, MF Hivert, RA Scott, JL Grimsby, N Bouatia-Naji, H Chen, D Rybin, CT Liu, LF Bielak, I Prokopenko, N Amin, D Barnes, G Cadby, JJ Hottenga, E Ingelsson, AU Jackson, T Johnson, S Kanoni, C Ladenvall, V Lagou, J Lahti, C Lecoeur, Y Liu, MT Martinez-Larrad, ME Montasser, P Navarro, JR Perry, LJ Rasmussen-Torvik, P Salo, N Sattar, D Shungin, RJ Strawbridge, T Tanaka, CM van Duijn, P An, M de Andrade, JS Andrews, T Aspelund, M Atalay, Y Aulchenko, B Balkau, S Bandinelli, JS Beckmann, JP Beilby, C Bellis, RN Bergman, J Blangero, M Boban, M Boehnke, E Boerwinkle, LL Bonnycastle, DI Boomsma, IB Borecki, Y Böttcher, C Bouchard, E Brunner, D Budimir, H Campbell, O Carlson, PS Chines, R Clarke, FS Collins, A Corbatón-Anchuelo, D Couper, U de Faire, GV Dedoussis, P Deloukas, M Dimitriou, JM Egan, G Eiriksdottir, MR Erdos, JG Eriksson, E Eury, L Ferrucci, I Ford, NG Forouhi, CS Fox, MG Franzosi, PW Franks, TM Frayling, P Froguel, P Galan, E de Geus, B Gigante, NL Glazer, A Goel, L Groop, V Gudnason, G Hallmans, A Hamsten, O Hansson, TB Harris, C Hayward, S Heath, S Hercberg, AA Hicks, A Hingorani, A Hofman, J Hui, J Hung, MR Jarvelin, MA Jhun, PC Johnson, JW Jukema, A Jula, WH Kao, J Kaprio, SL Kardia, S Keinanen-Kiukaanniemi, M Kivimaki, I Kolcic, P Kovacs, M Kumari, J Kuusisto, KO Kyvik, M Laakso, T Lakka, L Lannfelt, GM Lathrop, LJ Launer, K Leander, G Li, L Lind, J Lindstrom, S Lobbens, RJ Loos, J Luan, V Lyssenko, R Mägi, PK Magnusson, M Marmot, P Meneton, KL Mohlke, V Mooser, MA Morken, I Miljkovic, N Narisu, J O'Connell, KK Ong, BA Oostra, LJ Palmer, A Palotie, JS Pankow, JF Peden, NL Pedersen, M Pehlic, L Peltonen, B Penninx, M Pericic, M Perola, L Perusse, PA Peyser, O Polasek, PP Pramstaller, MA Province, K Räikkönen, R Rauramaa, E Rehnberg, K Rice, JI Rotter, I Rudan, A Ruokonen, T Saaristo, M Sabater-Lleal, V Salomaa, DB Savage, R Saxena, P Schwarz, U Seedorf, B Sennblad, M Serrano-Rios, AR Shuldiner, EJ Sijbrands, DS Siscovick, JH Smit, KS Small, NL Smith, AV Smith, A Stančáková, K Stirrups, M Stumvoll, YV Sun, AJ Swift, A Tönjes, J Tuomilehto, S Trompet, AG Uitterlinden, M Uusitupa, M Vikström, V Vitart, MC Vohl, BF Voight, P Vollenweider, G Waeber, DM Waterworth, H Watkins, E Wheeler, E Widen, SH Wild, SM Willems, G Willemsen, JF Wilson, JC Witteman, AF Wright, H Yaghootkar, D Zelenika, T Zemunik, L Zgaga, NJ Wareham, MI McCarthy, I Barroso, RM Watanabe, JC Florez, J Dupuis, JB Meigs, C Langenberg

TITLE:

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

JOURNAL:

Nature genetics May 2012, Vol 44, pp. 659-69

ABSTRACT:

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology. PUBMED: 22581228
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