GNF2_GSTM1
Neighborhood of GSTM1
c4 - Computational genesets defined by mining large collections of cancer-oriented microarray data.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bladder cancer. The EFO term bladder carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Rothman, M Garcia-Closas, N Chatterjee, N Malats, X Wu, JD Figueroa, FX Real, D Van Den Berg, G Matullo, D Baris, M Thun, LA Kiemeney, P Vineis, I De Vivo, D Albanes, MP Purdue, T Rafnar, MA Hildebrandt, AE Kiltie, O Cussenot, K Golka, R Kumar, JA Taylor, JI Mayordomo, KB Jacobs, M Kogevinas, A Hutchinson, Z Wang, YP Fu, L Prokunina-Olsson, L Burdett, M Yeager, W Wheeler, A Tardón, C Serra, A Carrato, R GarcÃa-Closas, J Lloreta, A Johnson, M Schwenn, MR Karagas, A Schned, G Andriole, R Grubb, A Black, EJ Jacobs, WR Diver, SM Gapstur, SJ Weinstein, J Virtamo, VK Cortessis, M Gago-Dominguez, MC Pike, MC Stern, JM Yuan, DJ Hunter, M McGrath, CP Dinney, B Czerniak, M Chen, H Yang, SH Vermeulen, KK Aben, JA Witjes, RR Makkinje, P Sulem, S Besenbacher, K Stefansson, E Riboli, P Brennan, S Panico, C Navarro, NE Allen, HB Bueno-de-Mesquita, D Trichopoulos, N Caporaso, MT Landi, F Canzian, B Ljungberg, A Tjonneland, F Clavel-Chapelon, DT Bishop, MT Teo, MA Knowles, S Guarrera, S Polidoro, F Ricceri, C Sacerdote, A Allione, G Cancel-Tassin, S Selinski, JG Hengstler, H Dietrich, T Fletcher, P Rudnai, E Gurzau, K Koppova, SC Bolick, A Godfrey, Z Xu, JI Sanz-Velez, M D GarcÃa-Prats, M Sanchez, G Valdivia, S Porru, S Benhamou, RN Hoover, JF Fraumeni, DT Silverman, SJ Chanock
Cerebellum Gene Expression Correlates for ZM_LATENCY measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The ZM_LATENCY measures Zero Maze - Latency to enter an open quadrant under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VERCNT135 measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VERCNT135 measures Morphine vertical activity counts minutes 120-135 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VERCNT165 measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VERCNT165 measures Morphine vertical activity counts minutes 150-165 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
All genes listed were differentially expressed between selectively bred HAP and LAP mice using both normalization methods (RMA and MAS5.0), using two different statistical analyses (permutation and t-test noise distribution), and in both the original and replicate lines at a p value of 0.20 or less and they also had a significant (p < 0.05) or suggestive (0.05 < p < 0.10) eQTL that was located within a bQTL for alcohol preference (2-bottle choice); from Saba et al., 2006
Authors:
Saba L, Bhave SV, Grahame N, Bice P, Lapadat R, Belknap J, Hoffman PL, Tabakoff B
QTL for ethanol conditioned taste aversion on Chr3 at D3Mit11 (111.75 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 86.75 - 136.75 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for body temperature on Chr3 at Gnat2 (111.75 Mbp , Build 37)
Description:
METH responses for body temperature spans 86.75 - 136.75 Mbp (NCBI Build 37) on Chr3. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - Cocaine-paired (conditioned place preference) vs. Control (saline or cocaine-non-paired) DNA microarray All genes on microarray presented After the pre-conditioning phase where animals were allowed access to either compartment for 15 minutes for 4 consecutive days, the conditioning phase for the cocaine-paired groups and cocaine non-paired groups began, consisting of eight subsequent daily sessions. For both groups, cocaine (10 mg / kg) or saline injections were administered on alternate days. For the cocaine-paired groups, rats were immediately placed in one of the two compartments for 30 min with the door in place restricting a z transformation followed by z test and anova followed by Student-Newman-Keuls' post hoc test. Gene expression profile was assessed 24 h after the last conditioning session that corresponded to 48 h after last cocaine exposure, when drug has been eliminated from the body and transient transcriptional changes are likely to be minimal. Therefore, changes in gene expression at this time-point are likely to reflect longer lasting adaptations that may account for maintenance of cocaine-induced memories. The complete lists of normalized gene expression values for the hippocampus of saline-treated, cocaine non-paired and cocaine-paired groups are presented. Analyses revealed that 214 transcripts were differentially regulated in the hippocampus of cocaine-paired rats vs. non-paired and saline-treated controls. Cocaine-induced conditioned place preference caused significant increases in the expression of 151 genes and caused decreases in the expression of 63 genes. (NIF Table ID 130.1 [83])
Authors:
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL
Chronic cocaine - Cocaine-paired (conditioned place preference) vs. Control (saline or cocaine-non-paired) DNA microarray All genes on microarray presented After the pre-conditioning phase where animals were allowed access to either compartment for 15 minutes for 4 consecutive days, the conditioning phase for the cocaine-paired groups and cocaine non-paired groups began, consisting of eight subsequent daily sessions. For both groups, cocaine (10 mg / kg) or saline injections were administered on alternate days. For the cocaine-paired groups, rats were immediately placed in one of the two compartments for 30 min with the door in place restricting a z transformation followed by z test and anova followed by Student-Newman-Keuls' post hoc test. Gene expression profile was assessed 24 h after the last conditioning session that corresponded to 48 h after last cocaine exposure, when drug has been eliminated from the body and transient transcriptional changes are likely to be minimal. Therefore, changes in gene expression at this time-point are likely to reflect longer lasting adaptations that may account for maintenance of cocaine-induced memories. The complete lists of normalized gene expression values for the frontal cortex of saline-treated, cocaine non-paired and cocaine-paired groups are presented. Differences in the expression of 39 transcripts in the frontal cortex were related to the conditioned place preference paradigm. These include increases in the level of 22 genes and decreases in 17 genes. (NIF Table ID 130.3 [83.5])
Authors:
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL
Genes associated with Homo sapiens that interact with the MeSH term 'Azaguanine' (D001375). Incorporates data from 134 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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