GeneSet Information

Tier III GS75745 • Candidate genes for alcohol preference in brains of HAP and LAP mice

DESCRIPTION:

All genes listed were differentially expressed between selectively bred HAP and LAP mice using both normalization methods (RMA and MAS5.0), using two different statistical analyses (permutation and t-test noise distribution), and in both the original and replicate lines at a p value of 0.20 or less and they also had a significant (p < 0.05) or suggestive (0.05 < p < 0.10) eQTL that was located within a bQTL for alcohol preference (2-bottle choice); from Saba et al., 2006

LABEL:

hap lap mice

SCORE TYPE:

P-Value

DATE ADDED:

2010-06-30

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Saba L, Bhave SV, Grahame N, Bice P, Lapadat R, Belknap J, Hoffman PL, Tabakoff B

TITLE:

Candidate genes and their regulatory elements: alcohol preference and tolerance.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Jun 2006, Vol 17, pp. 669-88

ABSTRACT:

QTL analysis of behavioral traits and mouse brain gene expression studies were combined to identify candidate genes involved in the traits of alcohol preference and acute functional alcohol tolerance. The systematic application of normalization and statistical analysis of differential gene expression, behavioral and expression QTL location, and informatics methodologies resulted in identification of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance. Pathway analysis, combined with clustering by ontology, indicated the importance of transcriptional regulation and DNA and protein binding elements in the acute functional tolerance trait, and protein kinases and intracellular signal transduction elements in the alcohol preference trait. A rudimentary search for transcription control elements that could indicate coregulation of the panels of candidate genes produced modest results, implicating SMAD-3 in the regulation of four of the eight candidate genes for alcohol preference. However, the realization of the many caveats related to transcription factor binding site analysis, and attempts to correlate between transcription factor binding and function, forestalled any definitive global analysis of transcriptional control of differentially expressed candidate genes. PUBMED: 16783646
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Annotation Information

No sequence read archive data associated with this GeneSet.


Social Control, Formal (D012926)
Brain (D001921)
Noise (D009622)
Protein Binding (D011485)
Animals (D000818)
DNA (D004247)
Mice (D051379)
Alcohol Drinking (D000428)
Binding Sites (D001665)
Drug Tolerance (D004361)
Informatics (D048088)
Mice, Inbred C57BL (D008810)
Mice, Inbred DBA (D008811)
Transcription Factors (D014157)
Protein Kinases (D011494)
Methods (D008722)
Elements (D004602)
Phosphotransferases (D010770)
Identification (Psychology) (D007062)
Signal Transduction (D015398)
Genes, Regulator (D005809)
Cluster Analysis (D016000)
brain (MA:0000168)
alcohol preference (MP:0001987)
intracellular (GO:0005622)
protein binding (GO:0005515)
transcription factor binding (GO:0008134)
transduction (GO:0009293)
binding (GO:0005488)
intracellular signal transduction (GO:0035556)
signal transduction (GO:0007165)
gene expression (GO:0010467)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351