DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bladder cancer. The EFO term bladder carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: bladder carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Rothman, M Garcia-Closas, N Chatterjee, N Malats, X Wu, JD Figueroa, FX Real, D Van Den Berg, G Matullo, D Baris, M Thun, LA Kiemeney, P Vineis, I De Vivo, D Albanes, MP Purdue, T Rafnar, MA Hildebrandt, AE Kiltie, O Cussenot, K Golka, R Kumar, JA Taylor, JI Mayordomo, KB Jacobs, M Kogevinas, A Hutchinson, Z Wang, YP Fu, L Prokunina-Olsson, L Burdett, M Yeager, W Wheeler, A Tardón, C Serra, A Carrato, R García-Closas, J Lloreta, A Johnson, M Schwenn, MR Karagas, A Schned, G Andriole, R Grubb, A Black, EJ Jacobs, WR Diver, SM Gapstur, SJ Weinstein, J Virtamo, VK Cortessis, M Gago-Dominguez, MC Pike, MC Stern, JM Yuan, DJ Hunter, M McGrath, CP Dinney, B Czerniak, M Chen, H Yang, SH Vermeulen, KK Aben, JA Witjes, RR Makkinje, P Sulem, S Besenbacher, K Stefansson, E Riboli, P Brennan, S Panico, C Navarro, NE Allen, HB Bueno-de-Mesquita, D Trichopoulos, N Caporaso, MT Landi, F Canzian, B Ljungberg, A Tjonneland, F Clavel-Chapelon, DT Bishop, MT Teo, MA Knowles, S Guarrera, S Polidoro, F Ricceri, C Sacerdote, A Allione, G Cancel-Tassin, S Selinski, JG Hengstler, H Dietrich, T Fletcher, P Rudnai, E Gurzau, K Koppova, SC Bolick, A Godfrey, Z Xu, JI Sanz-Velez, M D García-Prats, M Sanchez, G Valdivia, S Porru, S Benhamou, RN Hoover, JF Fraumeni, DT Silverman, SJ Chanock

TITLE:

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

JOURNAL:

Nature genetics Nov 2010, Vol 42, pp. 978-84

ABSTRACT:

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. PUBMED: 20972438
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