Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.
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Genes up-regulated in cisplatin resistant (Cdh1-/p53-) tumors following a brief cisplatin treatment vs untreated. The tumors were engineered. Changes in proteins levels in lystates were analyzed by in-gel digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS). Only genes with p values of 0.05 or less are used.
Only changes with p-values better than 0.05 are included.
Two genes did not map to MGI identifiers: "Pc" and Actbl
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Ulcerative colitis. The EFO term ulcerative colitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Barrett, JC Lee, CW Lees, NJ Prescott, CA Anderson, A Phillips, E Wesley, K Parnell, H Zhang, H Drummond, ER Nimmo, D Massey, K Blaszczyk, T Elliott, L Cotterill, H Dallal, AJ Lobo, C Mowat, JD Sanderson, DP Jewell, WG Newman, C Edwards, T Ahmad, JC Mansfield, J Satsangi, M Parkes, CG Mathew, P Donnelly, L Peltonen, JM Blackwell, E Bramon, MA Brown, JP Casas, A Corvin, N Craddock, P Deloukas, A Duncanson, J Jankowski, HS Markus, CG Mathew, MI McCarthy, CN Palmer, R Plomin, A Rautanen, SJ Sawcer, N Samani, RC Trembath, AC Viswanathan, N Wood, CC Spencer, JC Barrett, C Bellenguez, D Davison, C Freeman, A Strange, P Donnelly, C Langford, SE Hunt, S Edkins, R Gwilliam, H Blackburn, SJ Bumpstead, S Dronov, M Gillman, E Gray, N Hammond, A Jayakumar, OT McCann, J Liddle, ML Perez, SC Potter, R Ravindrarajah, M Ricketts, M Waller, P Weston, S Widaa, P Whittaker, P Deloukas, L Peltonen, CG Mathew, JM Blackwell, MA Brown, A Corvin, MI McCarthy, CC Spencer, AP Attwood, J Stephens, J Sambrook, WH Ouwehand, WL McArdle, SM Ring, DP Strachan
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
RS Houlston, E Webb, P Broderick, AM Pittman, MC Di Bernardo, S Lubbe, I Chandler, J Vijayakrishnan, K Sullivan, S Penegar, L Carvajal-Carmona, K Howarth, E Jaeger, SL Spain, A Walther, E Barclay, L Martin, M Gorman, E Domingo, AS Teixeira, D Kerr, JB Cazier, I Niittymäki, S Tuupanen, A Karhu, LA Aaltonen, IP Tomlinson, SM Farrington, A Tenesa, JG Prendergast, RA Barnetson, R Cetnarskyj, ME Porteous, PD Pharoah, T Koessler, J Hampe, S Buch, C Schafmayer, J Tepel, S Schreiber, H Völzke, J Chang-Claude, M Hoffmeister, H Brenner, BW Zanke, A Montpetit, TJ Hudson, S Gallinger, H Campbell, MG Dunlop
down -regulated with cisplatin of Cdh1-/p53- tumors
Description:
Genes up-regulated in cisplatin senstive (Cdh1-/p53-) tumors following a brief cisplatin treatment vs untreated. The tumors were engineered. Changes in proteins levels in lystates were analyzed by in-gel digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS). Only genes with p values of 0.05 or less are used.
Expression changes with p values better than 0.05 are shown.
Top tier were previously reported at genome-wide significance (5×10−8), bottom tier were previously reported with weaker evidence. P values are one-tailed in the direction of the previously reported association.
Authors:
Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Deloukas P, Peltonen L, Mathew CG, Blackwell JM, Brown MA, Corvin A, McCarthy MI, Spencer CC, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP
This gene set comprises 239 genes that are differentially expressed within each of five brain regions (amygdala, hippocampus, nucleus accumbens, prefrontal cortex and ventral tegmental area) when chronic nicotine treatment is administered to C57BL/6J mice only. Background: Studies involving use of chronic nicotine treatment identify unique nicotine addiction genes and the biological processes they control in B6 and C3 mice. Results are obtained using gene expression profiling and gene ontology.
Authors:
Wang J, Gutala R, Hwang YY, Kim JM, Konu O, Ma JZ, Li MD
QTL for METH responses for body temperature on Chr8 at D8Ncvs43 (95.66 Mbp , Build 37)
Description:
METH responses for body temperature spans 70.66 - 120.66 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with Homo sapiens that interact with the MeSH term 'entinostat' (C118739). Incorporates data from 11 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Azacitidine' (D001374). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Colchicine' (D003078). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Deoxyadenosines' (D003839). Incorporates data from 73 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one' (C093973). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '3-(4-methylphenylsulfonyl)-2-propenenitrile' (C434003). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Oikopleura dioica that interact with the MeSH term 'Clofibrate' (D002994). Incorporates data from 27 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Smoke' (D012906). Incorporates data from 54 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Fluorouracil' (D005472). Incorporates data from 99 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Bos taurus that interact with the MeSH term 'duroquinone' (C034257). Incorporates data from 16 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'afimoxifene' (C016601). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'diallyl disulfide' (C028009). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex' (C050950). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Diclofenac' (D004008). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'sorafenib' (C471405). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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