DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RS Houlston, E Webb, P Broderick, AM Pittman, MC Di Bernardo, S Lubbe, I Chandler, J Vijayakrishnan, K Sullivan, S Penegar, L Carvajal-Carmona, K Howarth, E Jaeger, SL Spain, A Walther, E Barclay, L Martin, M Gorman, E Domingo, AS Teixeira, D Kerr, JB Cazier, I Niittymäki, S Tuupanen, A Karhu, LA Aaltonen, IP Tomlinson, SM Farrington, A Tenesa, JG Prendergast, RA Barnetson, R Cetnarskyj, ME Porteous, PD Pharoah, T Koessler, J Hampe, S Buch, C Schafmayer, J Tepel, S Schreiber, H Völzke, J Chang-Claude, M Hoffmeister, H Brenner, BW Zanke, A Montpetit, TJ Hudson, S Gallinger, H Campbell, MG Dunlop

TITLE:

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

JOURNAL:

Nature genetics Dec 2008, Vol 40, pp. 1426-35

ABSTRACT:

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC. PUBMED: 19011631
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