DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Ulcerative colitis. The EFO term ulcerative colitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: ulcerative colitis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JC Barrett, JC Lee, CW Lees, NJ Prescott, CA Anderson, A Phillips, E Wesley, K Parnell, H Zhang, H Drummond, ER Nimmo, D Massey, K Blaszczyk, T Elliott, L Cotterill, H Dallal, AJ Lobo, C Mowat, JD Sanderson, DP Jewell, WG Newman, C Edwards, T Ahmad, JC Mansfield, J Satsangi, M Parkes, CG Mathew, P Donnelly, L Peltonen, JM Blackwell, E Bramon, MA Brown, JP Casas, A Corvin, N Craddock, P Deloukas, A Duncanson, J Jankowski, HS Markus, CG Mathew, MI McCarthy, CN Palmer, R Plomin, A Rautanen, SJ Sawcer, N Samani, RC Trembath, AC Viswanathan, N Wood, CC Spencer, JC Barrett, C Bellenguez, D Davison, C Freeman, A Strange, P Donnelly, C Langford, SE Hunt, S Edkins, R Gwilliam, H Blackburn, SJ Bumpstead, S Dronov, M Gillman, E Gray, N Hammond, A Jayakumar, OT McCann, J Liddle, ML Perez, SC Potter, R Ravindrarajah, M Ricketts, M Waller, P Weston, S Widaa, P Whittaker, P Deloukas, L Peltonen, CG Mathew, JM Blackwell, MA Brown, A Corvin, MI McCarthy, CC Spencer, AP Attwood, J Stephens, J Sambrook, WH Ouwehand, WL McArdle, SM Ring, DP Strachan

TITLE:

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

JOURNAL:

Nature genetics Dec 2009, Vol 41, pp. 1330-4

ABSTRACT:

Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 cases and 5,417 controls. Loci showing evidence of association at P < 1 x 10(-5) were followed up by genotyping in an independent set of 2,321 cases and 4,818 controls. We find genome-wide significant evidence of association at three new loci, each containing at least one biologically relevant candidate gene, on chromosomes 20q13 (HNF4A; P = 3.2 x 10(-17)), 16q22 (CDH1 and CDH3; P = 2.8 x 10(-8)) and 7q31 (LAMB1; P = 3.0 x 10(-8)). Of note, CDH1 has recently been associated with susceptibility to colorectal cancer, an established complication of longstanding ulcerative colitis. The new associations suggest that changes in the integrity of the intestinal epithelial barrier may contribute to the pathogenesis of ulcerative colitis. PUBMED: 19915572
Find other GeneSets from this publication