Voluntary alcohol consumption QTL 1. In the AXB/BXA RI series, significant linkage to alcohol preference mapped to 107 cM on mouse Chromosome 2 near D2Mit74 (LOD=6.13). This locus accounts for 30% of the variance in male and female mice and is named Vacq1 (voluntary alcohol consumption QTL 1). The Vacq1 QTL interval is defined by markers D2Mit148 (105 cM) and D2Mit266 (109 cM). C57BL/6J-derived alleles at Vacq1 confer increased alcohol consumption. Potential candidate genes for Vacq1 are Ntsr1 (107 cM) and Chrna4 (108 cM). Vacq1 appears to be influenced by a locus on mouse Chromosome 15 named Vacq2 (voluntary alcohol consumption QTL 2). Animals homozygous for C57BL/6J-derived alleles at both Vacq1 and Vacq2 exhibit significantly increased alcohol preference.
QTL associated with non-insulin-dependent diabetes mellitus 2 in NSY. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (60343804)
QTL associated with voluntary alcohol consumption QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (180579319)
QTL associated with experimental allergic encephalomyelitis susceptibility 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (178535250)
QTL associated with "alcohol preference locus 5, male specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (180579319)
QTL associated with "alcohol preference locus 6, female specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (180579319)
QTL associated with autoimmune ovarian dysgenesis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (162212535)
QTL associated with bone marrow graft rejection 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (167857642)
Authors:
Johansson MH, Taylor MA, Jagodic M, Tus K, Schatzle JD, Wakeland EK, Bennett M
QTL associated with cystic fibrosis lung disease 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (172807628)
QTL associated with duration of locomotor activity 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (169101357)
Authors:
Kelly MA, Low MJ, Phillips TJ, Wakeland EK, Yanagisawa M
QTL associated with experimental allergic encephalomyelitis susceptibility 20. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (28475226)
QTL associated with erosive arthritis susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (162170578)
Authors:
Mountz JD, Yang P, Wu Q, Zhou J, Tousson A, Fitzgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, Hsu HC
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