DESCRIPTION:

QTL associated with urinary albuminuria 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (165648473)

LABEL:

QTL-Ua1-Mouse-Chr 2

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3622170

AUTHORS:

Shike T, Gohda T, Tanimoto M, Kobayashi M, Makita Y, Funabiki K, Horikoshi S, Hirose S, Shirai T, Tomino Y

TITLE:

Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice.

JOURNAL:

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association May 2005, Vol 20, pp. 879-85

ABSTRACT:

The KK/Ta mouse strain serves as a suitable polygenic model for human type 2 diabetes. We previously reported a genome-wide linkage analysis of KK/Ta alleles contributing to type 2 diabetes and related phenotypes such as fasting hyperglycaemia, glucose intolerance, hyperinsulinaemia, obesity and dyslipidaemia.Since KK/Ta mice spontaneously develop renal lesions closely resembling those in human diabetic nephropathy, we investigated the susceptibility loci using the KK/Ta x (BALB/c x KK/Ta) F1 backcross progeny in the present study.A genome-wide analysis of susceptibility loci for albuminuria with microsatellite-based chromosomal maps showed a contributing KK/Ta locus, provisionally designated UA-1, with a significant linkage with the interval on chromosome 2 at 83.0 cM close to the microsatellite marker D2Mit311 with a maximum LOD of 3.5 (chi(2) = 13.2, P = 0.0003). UA-1 was different from the susceptibility loci contributing to type 2 diabetes, which we earlier identified. The mode of inheritance differed from that of hypertension. The progeny homozygous for UA-1 showed significantly higher urinary albumin levels.Although there were no significant correlations between urinary albumin levels and other diabetic phenotypes, the group of progeny homozygous for both UA-1 and alleles for fasting hyperglycaemia showed the highest urinary albumin levels. Thus, UA-1 appears to increase the risk of diabetic nephropathy, particularly in individuals susceptible to fasting hyperglycaemia, in a gene dosage-dependent manner. There are potentially important candidate genes that may be relevant to diabetic nephropathy. PUBMED: 15769825
Find other GeneSets from this publication