GeneSet Information

Tier II GS135442 • bone marrow graft rejection 3 (Bmgr3, Published QTL Chr 2)

DESCRIPTION:

QTL associated with bone marrow graft rejection 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (167857642)

LABEL:

QTL-Bmgr3-Mouse-Chr 2

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Johansson MH, Taylor MA, Jagodic M, Tus K, Schatzle JD, Wakeland EK, Bennett M

TITLE:

Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.

JOURNAL:

Journal of immunology (Baltimore, Md. : 1950) Dec 2006, Vol 177, pp. 7923-9

ABSTRACT:

NK cells reject allogeneic and MHC class I-deficient bone marrow (BM) grafts in vivo. The mechanisms used by NK cells to mediate this rejection are not yet thoroughly characterized. Although perforin plays a major role, perforin-independent mechanisms are involved as well. C57BL/6 mice deficient in perforin (B6 perforin knockout (PKO)) reject class I-deficient TAP-1 KO BM cells as efficiently as normal B6 mice. In contrast, perforin-deficient 129S6/SvEvTac mice (129 PKO) cannot mediate this rejection while normal 129 mice efficiently reject. This suggests that in 129, but not in B6, mice, perforin is crucial for NK cell-mediated rejection of MHC class I-deficient BM grafts. To identify loci linked to BM rejection in perforin-deficient mice, we generated backcross 1 progeny by crossing (129 x B6)F(1) PKO mice to 129 PKO mice. In transplantation experiments, >350 backcross 1 progeny were analyzed and displayed a great variation in ability to reject TAP-1 KO BM grafts. PCR-based microsatellite mapping identified four quantitative trait loci (QTL) on chromosomes 2, 4, and 8, with the QTL on chromosome 8 showing the highest significance, as well as a fifth epistatic QTL on chromosome 3. This study describes the first important step toward identifying BM graft resistance gene(s). PUBMED: 17114464
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Annotation Information



Aptitude (D001076)
Chromosomes, Human, Pair 8 (D002898)
Chromosomes, Human, Pair 3 (D002893)
Bone Marrow (D001853)
Rejection (Psychology) (D012059)
Major Histocompatibility Complex (D008285)
Play and Playthings (D010988)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Microsatellite Repeats (D018895)
Graft Rejection (D006084)
Mice, 129 Strain (D057507)
Transplants (D019737)
Classification (D002965)
Transplantation (D014180)
Killer Cells, Natural (D007694)
Perforin (D054353)
Bone and Bones (D001842)
bone marrow (MA:0000134)
chromosome (GO:0005694)

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