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					GeneSet Title
	Tier V	Human		29 Genes	GS273238 Genes up-regulated in Brac1 sensitive breast cancer cells
					LABEL: Up_BRAC1_sens DESCRIPTION: Genes up-regulated in BRCA1-deficient mammary tumours after brief cisplatin treatment. Gene set restricted to those with p value less than 0.05
	Tier V	Human		29 Genes	GS273239 Genes up-regulated in cisplatin (Brac1-) sensitive breast cancer cells
					LABEL: Up_BRAC1-_sens DESCRIPTION: Genes up-regulated in Cisplatin senstive (BRCA1-deficient )mammary tumours after brief cisplatin treatment vs untreated.. Gene set restricted to those with p value less than 0.05 Note: Cisplatin sensitve tumors are Brac1-, p53- Note: Cisplatin resistant tumors are Cdh1-, p53- Protein levels determined by isolation of 2D gel spots with subsequent analysis by In-gel Digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS) Genes not found: as of 10/25/2017; working NUP21 1.9x U2SUR 2.4x FAM76 100x GSTT3 2.9x THRAP 2.5x SLC16 6x
	Tier V	Mouse		29 Genes	GS273240 Genes up-regulated in cisplatin (Brac1-) sensitive breast cancer cells
					LABEL: Up_BRAC1-_sens DESCRIPTION: Genes up-regulated in Cisplatin senstive (BRCA1-deficient mouse )mammary tumours after brief cisplatin treatment vs untreated.. Gene set restricted to those with p value less than 0.05 Note: Cisplatin sensitve tumors are Brac1-, p53- Note: Cisplatin resistant tumors are Cdh1-, p53- Protein levels determined by isolation of 2D gel spots with subsequent analysis by In-gel Digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS) Genes not found: as of 10/25/2017; working NUP21 1.9x U2SUR 2.4x FAM76 100x GSTT3 2.9x THRAP 2.5x SLC16 6x
	Tier III	Mouse		28 Genes	GS273242 Genes up-regulated with cisplatin treatment of cisplatin sensitive (Brca1-) mouse tumors
					LABEL: up-regulated with cisplatin of Brac1-/p53- tumors DESCRIPTION: Genes up-regulated in cisplatin senstive (Brca1-/p53-) tumors following a brief cisplatin treatment vs untreated. The tumors were engineered. Changes in proteins levels in lystates were analyzed by in-gel digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS). Only genes with p values of 0.05 or less are used. This set should be compared to three other sets from this publication:down-regulated with cisplatin in Brac1-tumors and up/down regulated with cisplatin in Cdh1-/;p53- Genes were mapped to MGI identifiers. The following genes were not mapped: Nup21, C6orf1, Fam76, Thrap, U2sur, and Slc16
	Tier III	Mouse		6 Genes	GS273243 Genes down-regulated with cisplatin treatment of cisplatin sensitive (Brca1-) mouse tumors
					LABEL: down-regulated with cisplatin of Brac1-/p53- tumors DESCRIPTION: Genes down-regulated in cisplatin senstive (Brca1-/p53-) tumors following a brief cisplatin treatment vs untreated. The tumors were engineered. Changes in proteins levels in lystates were analyzed by in-gel digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS). Only genes with p values of 0.05 or less are used.
	Tier III	Mouse		6 Genes	GS273287 Genes down-regulated with cisplatin treatment of cisplatin resistant mouse tumors
					LABEL: down -regulated with cisplatin of Cdh1-/p53- tumors DESCRIPTION: Genes up-regulated in cisplatin senstive (Cdh1-/p53-) tumors following a brief cisplatin treatment vs untreated. The tumors were engineered. Changes in proteins levels in lystates were analyzed by in-gel digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS). Only genes with p values of 0.05 or less are used. Expression changes with p values better than 0.05 are shown.
	Tier III	Mouse		5 Genes	GS273288 Genes up-regulated with cisplatin treatment of cisplatin resistant (Cdh1-/p53-) mouse tumors
					LABEL: up-regulated with cisplatin of Cdh1-/p53- tumors DESCRIPTION: Genes up-regulated in cisplatin resistant (Cdh1-/p53-) tumors following a brief cisplatin treatment vs untreated. The tumors were engineered. Changes in proteins levels in lystates were analyzed by in-gel digestion and Nano-liquid Chromatography-Fourier Transformation-Mass Spectrometry (nanoLC-FT-MS). Only genes with p values of 0.05 or less are used. Only changes with p-values better than 0.05 are included. Two genes did not map to MGI identifiers: "Pc" and Actbl

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351