GeneSet Information

Tier IV GS380553 • Up-regulated Immune genes involved in response to Coronovirus avian infectious bronchitis infection in chicken kidney

from Publication Assignment: 352

DESCRIPTION:

One day old specific pathogen-free White Leghorn chicks were intra-nasally inoculated with Avian infectious bronchitis virus (IBV). Total RNA was extracted from of uninfected birds or those that died from IBV infection. Samples were hybridized to a Agilent custom checken oligo microarray. The GO category for biological process and KEGG pathway analysis for carried out for differentially expressed (DE) genes, and P value < 0.05 and a FDR of < 0.05 was used as a threshold. The DE genes mainly clustered into 12 functional groups. Here genes up-regulated that are associated with innate immune response are shown. Genes were considered to be significantly u--regulated or down-regulated if the change in their relative expression levels was > 2-fold or < 2-fold. The following gene symbols were not annotated in this gene set as they were not found in GeneWeaver IL1R1, JUN, DUSP4, VNN1, TLR4 and C1R.

LABEL:

Up-regulated Immune genes in chicken

SCORE TYPE:

Effect

DATE ADDED:

2020-04-28

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Feng Cong, Xiaoli Liu, Zongxi Han, Yuhao Shao, Xiangang Kong, Shengwang Liu

TITLE:

Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infection.

JOURNAL:

BMC genomics Oct 2013, Vol 14, pp. 743

ABSTRACT:

Infectious bronchitis virus (IBV), a prototype of the Coronaviridae family, is an economically important causative agent of infectious bronchitis in chickens and causes an acute and highly contagious upper respiratory tract infections that may lead to nephritis. However, the molecular antiviral mechanisms of chickens to IBV infection remain poorly understood. In this study, we conducted global gene expression profiling of chicken kidney tissue after nephropathogenic IBV infection to better understand the interactions between host and virus. PUBMED: 24168272
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Annotation Information

No sequence read archive data associated with this GeneSet.


kidney inflammation (MP:0001859)
biological_process (GO:0008150)
innate immune response (GO:0045087)
immune response (GO:0006955)
gene expression (GO:0010467)
lead atom (CHEBI:25016)
antiviral agent (CHEBI:22587)
host of (RO:0002453)
expressed in (RO:0002206)
proximo-distal subdivision of respiratory tract (UBERON:0000072)
upper respiratory tract (UBERON:0001557)
diencephalon (UBERON:0001894)
respiratory tract (UBERON:0000065)
anatomical projection (UBERON:0004529)

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