Warning: You're using a guest account.
Unless you register as a full user all information associated with this session will be deleted within 24 hours.
QTL associated with lung tumor shape-determining 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
QTL for nicotine sensitivity on Chr8 at D8Mit124 (13.44 Mbp , Build 37)
Description:
nicotine sensitivity spans 0.00 - 38.44 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
alcohol preference spans 0.00 - 40.29 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bachmanov AA, Reed DR, Li X, Li S, Beauchamp GK, Tordoff MG
Differential Expression of Emotional and Physical Stress(Fold Change >1) in Ventral Tegmental Area using eight week-old male C57BL/6J. Statistics reported as fold change.
Authors:
Warren BL, Vialou VF, Alcantara LF, Wright KN, Feng J, Kennedy PJ, Laplant Q, Shen L, Nestler EJ
QTL associated with Alzheimer's disease modifier 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (27830259)
Authors:
Sebastiani G, Krzywkowski P, Dudal S, Yu M, Paquette J, Malo D, Gervais F, Tremblay P
QTL associated with experimental allergic encephalomyelitis susceptibility 24. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
QTL associated with susceptibility to lung cancer 20. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
QTL associated with directional asymmetry QTL 19. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33127016)
QTL associated with proteoglycan induced arthritis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34189817)
Authors:
Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K
QTL associated with nicotine induced locomotor activity 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (14723160)
QTL associated with platelet-binding antibody-associated thrombocytopenia 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (30715154)
Authors:
Ida A, Hirose S, Hamano Y, Kodera S, Jiang Y, Abe M, Zhang D, Nishimura H, Shirai T
QTL associated with protection against vaginal candidiasis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (4976602)
QTL associated with colon tumor susceptibility 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (13397210)
Authors:
van Wezel T, Ruivenkamp CA, Stassen AP, Moen CJ, Demant P