Genes associated with Homo sapiens that interact with the MeSH term 'Silicon Dioxide' (D012822). Incorporates data from 9 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
QTL Associated with Consumption level. On Chromosome 2 with a LOD score= 2, p-value =0.592. From a(n) of QTL Associated with Consumption level. On Chromosome 6 with a LOD score= 2.6, p-value =0.224. From a(n) of QTL Associated with Spike wave discharge measurement. On Chromosome 7 with a LOD score= 3.68, p-value =2.00E-04. From a(n) of
Authors:
Rudolf G, Bihoreau MT, Godfrey RF, Wilder SP, Cox RD, Lathrop M, Marescaux C, Gauguier D
GSE26928_CENTR_MEMORY_VS_CXCR5_POS_CD4_TCELL_UP
Genes up-regulated in comparison of CD4 <a href='http://www.ncbi.nlm.nih.gov/gene/920'>[GeneID=920]</a> central memory T cells versus CD4 <a href='http://www.ncbi.nlm.nih.gov/gene/920'>[GeneID=920]</a> CXCR5+ <a href='http://www.ncbi.nlm.nih.gov/gene/643'>[GeneID=643]</a> T cells.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
chr12q13
Genes in cytogenetic band chr12q13
c1 - Positional genesets for each human chromosome and cytogenetic band.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
The dataset used in this study (Bulk RNA-Seq) was previously published and can be found at NCBI GEO (GSE182321), this analysis was conducted by GEO2R to compare control and OUD samples, only top differentially expressed genes are reported. To understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobiological alterations in OUD from the dorsolateral prefrontal cortex (Brodmann Area 9, BA9), we explored the role of microRNAs (miRNA) as powerful epigenetic regulators of gene function.
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