DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 7 with a LOD score= , p-value =0.001. From a(n) intercross of

LABEL:

QTL-Bp335-Rat-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Garrett MR, Rapp JP

TITLE:

Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 14, pp. 268-73

ABSTRACT:

1. Mamm Genome. 2003 Apr;14(4):268-73. Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Garrett MR(1), Rapp JP. Author information: (1)Department of Physiology and Molecular Medicine, Medical College of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614-5805, USA. mgarrett@mco.edu Previously we reported that there is a blood pressure quantitative trait locus (QTL) on rat Chromosome (Chr) 7 seen when comparing Dahl salt-sensitive (S) rats and Dahl salt-resistant (R) rats. Evidence was also presented that this QTL was due to genetic variants in the adrenal steroidogenic enzyme 11beta-hydroxylase ( Cyp11b1). A series of congenic strains supported this contention. In the present work we have constructed a final congenic substrain that retains a blood pressure effect and that has an introgressed congenic segment which includes Cyp11b1 and is < 177 kb in size. None of the other genes in the congenic region (eight known genes) have known biological functions for influencing blood pressure. We believe that we have reached the limit of resolution for congenic analysis of a QTL in a rodent animal model, and we conclude that Cyp11b1 causes the observed QTL on rat Chr 7 in Dahl rats. PMID: 12682779 [PubMed - indexed for MEDLINE] PUBMED: 12682779
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