Cerebellum Gene Expression Correlates for NX_ACOUNT_3 measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The NX_ACOUNT_3 measures Naloxone induced Morphine Withdrawal TOTAL photocell counts in 15 minutes under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for METH responses for body temperature on Chr6 at D6Nds2 (89.57 Mbp , Build 37)
Description:
METH responses for body temperature spans 64.57 - 114.57 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for high-dose ethanol actions on Chr6 at D6Mit67 (91.93 Mbp , Build 37)
Description:
high-dose ethanol actions spans 66.93 - 116.93 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
QTL for differences in cocaine responsiveness on Chr6 at D6Nds2 (93.28 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 68.28 - 118.28 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for high-dose ethanol actions on Chr6 at D6Mit36 (99.58 Mbp , Build 37)
Description:
high-dose ethanol actions spans 74.58 - 124.58 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
QTL for METH responses for home cage activity on Chr6 at II5ra (101.18 Mbp , Build 37)
Description:
METH responses for home cage activity spans 76.18 - 126.18 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic ethanol - Ethanol vs. Control DNA microarray Change in gene expression - Class II Alcoholics were classified based on the quantity of alcohol consumed, according to the National Health and Medical Research Council (NHMRC) (>80 g of alcohol per day), instead of the criteria established by the American Psychiatric Association (DSM-IV) or the World Health Organization (ICD-10). Many alcoholic patients in this study consumed significantly more than 80 g / day for most of their adult life. Cerebral atrophy was observed in three alcoholic cases. All alcoholic cases included in our Axon GenePix 4.0 software; partial least squares (PLS) statistical procedure; linear discriminant analysis (LDA) procedure for prediction analysis. PLS and LDA analysis were performed using in JMP IN software; principal component analysis (PCA) used STATISTICA software. Results reflect the combined dataset: Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. They represent those that were more likely turned off or turned on as a result of alcohol abuse. Class II genes were consistently detected in both groups. They represent consistently expressed genes for which quantitative differences in expression could be determined. (NIF Method ID 157)
Genes associated with Homo sapiens that interact with the MeSH term 'Amiodarone' (D000638). Incorporates data from 38 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'rosiglitazone' (C089730). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Copper Sulfate' (D019327). Incorporates data from 72 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Atrazine' (D001280). Incorporates data from 48 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Valproic Acid' (D014635). Incorporates data from 1238 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Rats in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks. Additive QTL. Variance 11 , LOD 9.2 Peak Marker: D4Rat34 spans D4Mgh9(54828166) - D4Mit9(152570244). Strains were P, NP. Also known as Eoh1.
Authors:
Carr LG, Habegger K, Spence JP, Liu L, Lumeng L, Foroud T
Rats in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the ethanol consumed were measured every 2 days over two weeks. Additive QTL. Variance 18, p-value 0.00015, LOD 3.6 Peak Marker: D4Rat57 spans D4Rat24(110970166)- D4Mit20(158108528) Strains were WKY, HEP. Also known as Coet10 (consumption of ethanol 10%).
Authors:
Terenina-Rigaldie E, Moisan MP, Colas A, Beaug F, Shah KV, Jones BC, Mormde P
Rats in separate cage with free choice of water or 5% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the ethanol consumed were measured every 2 days over two weeks. Additive QTL. Variance 61, p-value 0.00003, LOD 7.6 Peak Marker: D4Rat124 spans D4Rat24(77208508)- D4Mit20(158108528) Strains were WKY, HEP. Also known as Coet5 (consumption of ethanol 5%).
Authors:
Terenina-Rigaldie E, Moisan MP, Colas A, Beaug F, Shah KV, Jones BC, Mormde P
Rotarod Baseline Chr# 6 rs6239023(94005991) with right flanking marker rs13459097(84840296) and left marker rs3718735 (101072507). This was mapped in 300 + (b6x129)F2 mice.
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