Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
Generated by gene2mesh v. 1.1.1
Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.
Generated by gene2mesh v. 1.1.1
Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies.
Generated by gene2mesh v. 1.1.1
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "C-MYC pathway" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is pid.
gene2pc v. 0.1.0
Last updated 2015.08.31
Validated targets of C-MYC transcriptional repression
Description:
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "Validated targets of C-MYC transcriptional repression" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is pid.
gene2pc v. 0.1.0
Last updated 2015.08.31
Validated targets of C-MYC transcriptional activation
Description:
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "Validated targets of C-MYC transcriptional activation" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is pid.
gene2pc v. 0.1.0
Last updated 2015.08.31
QTL associated with accelerator of polyoma-induced mammary tumors 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56068554)
Authors:
Cozma D, Lukes L, Rouse J, Qiu TH, Liu ET, Hunter KW
QTL associated with accelerator of polyoma-induced mammary tumors 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (101431148)
Authors:
Cozma D, Lukes L, Rouse J, Qiu TH, Liu ET, Hunter KW
This set describes somatic gene amplificationin a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 7.5cm tumor from a 91 year old female patient. The tumor had characterisitcs of high-grade basal-like histology with tumor infiltrating lymphocytes, with angio-lymphatic invasion and lymph node metastasis, and low EGFR and absent CK5 expression respectively. Additional data from this sample are reported in Gene Set #271935. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 1.5cm tumor from a 44 year old female patient. The tumor had characterisitcs of high-grade histology, with angio-lymphatic invasion and lymph-node metastasis, with high EGFR and high CK5 expression respectively. Data from the same sample are reported in Gene Set #271938. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplificationin a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 4.7cm tumor from a 55 year old female patient. The tumor had characterisitcs of high-grade basal-like histology with tumor infiltrating lymphocytes, without angiolymphatic invasion and lymph node metastasis, and with high EGFR and high CK5 expression respectively. Data from the same sample are described in Gene Set #271939. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 2.2cm tumor from a 45 year old female patient. The tumor had characterisitcs of high-grade basal-like histology, without angio-lymphatic invasion and without lymph-node metastasis, with low EGFR and high CK5 expression respectively. Data from this sample is also reported in Gene Set #271940. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 6cm tumor from a 48 year old female patient. The tumor had characterisitcs of high-grade basal-like histology with tumor infiltrating lymphocytes, with angio-lymphatic invasion and lymph node metastasis, and with high EGFR and high CK5 expression respectively. Data from this sample is also reported in Gene Set #271942. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 3.7cm tumor from a 53 year old female patient. The tumor had characterisitcs of high-grade histology with tumor infiltrating lymphocytes, without angio-lymphatic invasion, and with high EGFR and high CK5 expression respectively. Data from this sample is also reported in Gene Set #271943. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 3.1cm tumor from a 50 year old female patient. The tumor had characterisitcs of high-grade histology with tumor infiltrating lymphocytes, with angio-lymphatic invasion and lymph node metastasis, high EGFR and high CK5 expression respectively. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 3cm tumor from a 76 year old female patient. The tumor had characterisitcs of intermediate-grade histology, with angio-lymphatic invasion but without lymph node metastasis,and with high EGFR and high CK5 expression respectively. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 3cm tumor from a 76 year old female patient. The tumor had characterisitcs of intermediate-grade histology, with angio-lymphatic invasion but without lymph node metastasis,and with high EGFR and high CK5 expression respectively. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 2.9cm tumor from a 30 year old female patient. The tumor had characterisitcs of high-grade basal-like histology with tumor infiltrating lymphocytes, without angio-lymphatic invasion and without lymph node metastasis, and with high EGFR and low CK5 expression respectively. Data from this set is also in Gene Set #271948. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 7.5cm tumor from a 59 year old female patient. The tumor had characterisitcs of high-grade histology, with angio-lymphatic invasion and lymph node metastasis and high EGFR and low CK5 expression respectively. Data from this sample is also described in Gene Set #271949. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic gene amplification in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 6cm tumor from a 55 year old female patient. The tumor had characterisitcs of high-grade basal-like histology, without angio-lymphatic invasion but with lymph node metastasis, and high EGFR and no CK5 expression respectively. Gene symbols were converted to HGNC identifiers for data entry.
This set describes somatic mutations in a patient diagnosed with triple-receptor negative breast cancer. The data is reported in Table 1. This sample was a 2.3cm tumor from a 52 year old female patient. The tumor had characterisitcs of high-grade histology, with angio-lymphatic invasion and lymph node metastasis, and high EGFR and no CK5 expression respectively. Gene symbols were converted to HGNC identifiers for data entry.
This gene set summarizes figure 1 and represents the percentage of clinically actionable gene amplifications detected in 20 tumors. The values represent the percentage of tumors with mutations. Gene symbols were converted to HGNC identifiers for data entry.
HALLMARK_MYC_TARGETS_V1
A subgroup of genes regulated by MYC - version 1 (v1).
h - Hallmark genesets containing coherently expressed signatures derived by aggregating many MSigDB gene sets to represent well-defined biological states or processes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
HALLMARK_MYC_TARGETS_V2
A subgroup of genes regulated by MYC - version 2 (v2).
h - Hallmark genesets containing coherently expressed signatures derived by aggregating many MSigDB gene sets to represent well-defined biological states or processes.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GeneWeaver