DESCRIPTION:

QTL Associated with Testicular weight. On Chromosome 7 with a LOD score= 3.28, p-value =. From a(n) intercross of

LABEL:

QTL-Teswt1-Rat-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Tachibana M, Lu L, Hiai H, Tamura A, Matsushima Y, Shisa H

TITLE:

Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats.

JOURNAL:

Experimental animals / Japanese Association for Laboratory Animal Science None None, Vol 55, pp. 91-5

ABSTRACT:

1. Exp Anim. 2006 Apr;55(2):91-5. Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats. Tachibana M(1), Lu L, Hiai H, Tamura A, Matsushima Y, Shisa H. Author information: (1)Saitama Cancer Center, Ina, Saitama, Japan. Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 x LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study. PMID: 16651691 [PubMed - indexed for MEDLINE] PUBMED: 16651691
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