QTL associated with amphetamine distance traveled 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20861477)
Authors:
Torkamanzehi A, Boksa P, Ayoubi M, Fortier ME, Ng Ying Kin NM, Skamene E, Rouleau G, Joober R
QTL associated with cocaine induced activation 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25567955)
QTL associated with circadian period of locomotor activity 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (26691206)
Authors:
Mayeda AR, Hofstetter JR, Belknap JK, Nurnberger JI Jr
QTL associated with darker modification of yellow agouti QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45435458)
QTL associated with lung squamous cell carcinoma 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (24071806)
Authors:
Wang Y, Zhang Z, Yan Y, Lemon WJ, LaRegina M, Morrison C, Lubet R, You M
QTL associated with neurotensin transcript abundance 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (24071806)
QTL associated with systematic lupus erythematosus susceptibility 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (19802051)
Authors:
Haywood ME, Hogarth MB, Slingsby JH, Rose SJ, Allen PJ, Thompson EM, Maibaum MA, Chandler P, Davies KA, Simpson E, Walport MJ, Morley BJ
QTL associated with thymocyte proliferative response 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (58290809)
Authors:
Hsu HC, Mountz JD, Williams RW, Shelton BJ, Yang PA, Matsuki Y, Xu X, Dodd CH, Li L, Geiger H, Zhang HG, Van Zant G
Genes that are induced by THC in total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are suppressed by THC in CD4 cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
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